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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomized controlled treatment trials
International Clinical Psychopharmacology, Volume 21, No. 6, Year 2006
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Description
Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive-compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine (<400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale-Brown Obsessive Compulsive Scale scores (P=0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission. © 2006 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Fineberg, Naomi Anne
United Kingdom, Hatfield
Hertfordshire Partnership University Nhs Foundation Trust
United Kingdom, Hatfield
University of Hertfordshire
United Kingdom, London
Imperial College London
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Welwyn Garden City
Queen Elizabeth Ii Hospital
Stein, Dan J.
South Africa, Stellenbosch
Stellenbosch University
Premkumar, Preethi
United Kingdom, London
King's College London
Carey, Paul D.
South Africa, Stellenbosch
Stellenbosch University
Sivakumaran, Thanusha
United Kingdom, Hatfield
Hertfordshire Partnership University Nhs Foundation Trust
Vythilingum, Bavanisha
South Africa, Stellenbosch
Stellenbosch University
Seedat, Soraya
South Africa, Stellenbosch
Stellenbosch University
Westenberg, Herman G.M.
Netherlands, Utrecht
University Medical Center Utrecht
Denys, Damiaan A.J.P.
Netherlands, Utrecht
University Medical Center Utrecht
Statistics
Citations: 98
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.1097/01.yic.0000215083.57801.11
ISSN:
02681315
Research Areas
Disability
Genetics And Genomics
Study Approach
Systematic review