Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Carbamazepine Clearance in Paediatric Epilepsy Patients: Influence of Body Mass, Dose, Sex and Co-Medication
Clinical Pharmacokinetics, Volume 17, No. 3, Year 1989
Notification
URL copied to clipboard!
Description
Carbamazepine clearance was studied in Black paediatric epilepsy patients, 90 receiving monotherapy and 17 on combination therapy. For patients on monotherapy the following relationships are shown: clearance decreases with increasing body mass (r = 0.87); clearance increases with increasing dose (r = 0.70); and mean clearances for males are higher than those for females throughout the mass ranges, though the difference is not statistically significant. In the case of patients on carbamazepine plus another anticonvulsant, clearance also decreases with increasing body mass, and increases with increasing dose. Furthermore, in the mass groups which corresponded with those on monotherapy, mean carbamazepine clearance is higher by a factor varying from 1.3 to 1.7; in the corresponding dosage groups, it is higher by a factor of between 1.4 and 1.7. © 1989, ADIS Press Limited. All rights reserved.
Authors & Co-Authors
Summers, Beverley
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Summers, Robert Stanley
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Statistics
Citations: 29
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.2165/00003088-198917030-00006
ISSN:
03125963
e-ISSN:
11791926
Participants Gender
Female