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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Are adolescents ready for tuberculosis vaccine trials?
Vaccine, Volume 26, No. 36, Year 2008
Notification
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Description
Tuberculosis (TB) vaccine trials are planned in adolescents in a high tuberculosis burden rural area near Cape Town, South Africa. To determine the knowledge and attitudes of adolescents about tuberculosis, vaccines and vaccine trials, a representative sample of adolescent learners was chosen from high schools in the trial area. A questionnaire was administered and focus group discussions held with the group and a sample of their parents. The questionnaire response rate was 65%. Knowledge of tuberculosis was fair 63.7% but knowledge of vaccines poor 41.9% based on a TB and vaccine knowledge score, respectively. Willingness to participate in vaccine trials will be influenced by the type of procedures involved (60% willing to answer questions, 43% willing to be examined, 32% willing to undergo skin tests and 39% willing to undergo blood draw). In general, better knowledge was statistically associated with greater willingness to participate in study procedures except for the blood draw. The focus group discussions showed that adolescents and their parents were positive about participating in vaccine trials but concerns about safety and the provision of adequate information should be considered when planning TB vaccine trials. This study suggests that TB vaccine trials would be acceptable amongst adolescents in this community with certain provisos. © 2008 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Mahomed, Hassan
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
South Africa, Cape Town
University of Cape Town
Shea, Jacqueline E.
South Africa, Cape Town
University of Cape Town
Kafaar, Fazlin
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
South Africa, Cape Town
University of Cape Town
Hawkridge, Tony
South Africa, Cape Town
Aeras Global tb Vaccine Foundation, South Africa
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
South Africa, Cape Town
University of Cape Town
Hussey, Greg Dudley
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 17
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.vaccine.2008.06.088
ISSN:
0264410X
Research Areas
Infectious Diseases
Study Approach
Qualitative
Study Locations
South Africa