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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Nature Communications, Volume 10, No. 1, Article 4558, Year 2019
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Description
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations. © 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM2_ESM.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM3_ESM.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM4_ESM.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM5_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM6_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6783435/bin/41467_2019_12576_MOESM7_ESM.pdf
Authors & Co-Authors
Nievergelt, Caroline M.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Maihofer, Adam X.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Klengel, Torsten
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Germany, Gottingen
Universitätsmedizin Göttingen
Atkinson, Elizabeth Grace
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Chen, Chia Yen
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Choi, Karmel W.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard T.h. Chan School of Public Health
Coleman, Jonathan R.I.
United Kingdom, London
King's College London
Dalvie, Shareefa
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Duncan, Laramie E.
United States, Palo Alto
Stanford University
Gelernter, Joel E.
United States, Washington, D.c.
U.s. Department of Veterans Affairs
United States, New Haven
Yale School of Medicine
United States, West Haven
Va Connecticut Healthcare System
Levey, Daniel F.
United States, West Haven
Va Connecticut Healthcare System
United States, New Haven
Yale School of Medicine
Logue, Mark W.
United States, West Roxbury
Va Boston Healthcare System
Polimanti, Renato
United States, West Haven
Va Connecticut Healthcare System
United States, New Haven
Yale School of Medicine
Provost, Allison C.
Unknown Affiliation
Ratanatharathorn, Andrew D.
United States, Boston
Harvard T.h. Chan School of Public Health
Stein, Murray B.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Torres, Katy
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Aiello, Allison E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Almli, Lynn M.
United States, Atlanta
Emory University
Amstadter, Ananda Beth
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Andersen, Søren Bo
Unknown Affiliation
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Arbisi, Paul A.
United States, Minneapolis
Va Midwest Health Care Network
Ashley-Koch, Allison E.
United States, Durham
Duke University
Austin, Sydney Bryn
United States, Boston
Harvard Medical School
United States, Boston
Boston Children's Hospital
United States, Boston
Channing Division of Network Medicine
United States, Boston
Harvard T.h. Chan School of Public Health
Avdibegović, Esmina
Bosnia and Herzegovina, Tuzla
University Clinical Center Tuzla
Babić, Dragan
Bosnia and Herzegovina, Mostar
University Clinical Hospital Mostar
Baekvad-Hansen, Marie
Denmark, Copenhagen
Statens Serum Institut
Baker, Dewleen G.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Beckham, Jean C.
United States, Durham
Durham va Medical Center
United States, Durham
Duke University
Bierut, Laura Jean
United States, St. Louis
Washington University School of Medicine in St. Louis
Bisson, Jonathan I.
United Kingdom, Cardiff
Mrc Centre for Neuropsychiatric Genetics and Genomics
Boks, Marco P.M.
Netherlands, Utrecht
University Medical Center Utrecht
Bolger, Elizabeth A.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
BØRglum, Anders Dupont
Denmark, Aarhus
Aarhus Universitet
Bradley-Davino, Bekh B.
United States, Atlanta
Emory University
United States, Decatur
Atlanta va Health Care System
Brashear, Meghan M.
United States, New Orleans
Lsu Health Sciences Center - new Orleans
Breen, Gerome D.
United Kingdom, London
King's College London
Bryant, Richard A.
Australia, Sydney
Unsw Sydney
Bustamante, Angela C.
United States, Ann Arbor
University of Michigan Medical School
Bybjerg-Grauholm, Jonas
Denmark, Copenhagen
Statens Serum Institut
Calabrese, Joseph R.
United States, Cleveland
University Hospitals Case Medical Center
Caldas-de-Almeida, José M.
Portugal, Lisbon
Lisbon Institute of Global Mental Health
Dale, Anders M.
United States, La Jolla
Department of Neurosciences
Daly, Mark J.
United States, Boston
Massachusetts General Hospital
Daskalakis, Nikolaos P.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
United States, New York
Icahn School of Medicine at Mount Sinai
Deckert, Jürgen
Germany, Wurzburg
Universitätsklinikum Würzburg
Delahanty, Douglas L.
United States, Kent
Kent State University
Dennis, Michelle F.
United States, Durham
Durham va Medical Center
United States, Durham
Duke University
Disner, Seth G.
United States, Minneapolis
Va Midwest Health Care Network
Domschke, Katharina
Germany, Freiburg Im Breisgau
Universität Freiburg
Džubur Kulenović, Alma
Unknown Affiliation
Erbes, Christopher R.
United States, Minneapolis
University of Minnesota Twin Cities
United States, Minneapolis
Va Midwest Health Care Network
Evans, Alexandra
United Kingdom, Cardiff
Cardiff University
Farrer, Lindsay A.
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Feeny, Norah C.
United States, Cleveland
Case Western Reserve University
Flory, Janine Dyck
United States, New York
Icahn School of Medicine at Mount Sinai
Forbes, David
Australia, Melbourne
University of Melbourne
Franz, Carol E.
United States, La Jolla
University of California, San Diego
Galea, Sandro
United States, Boston
Boston University
Garrett, Melanie E.
United States, Durham
Duke University
Gelaye, Bizu S.
United States, Boston
Harvard T.h. Chan School of Public Health
Geuze, Elbert
Netherlands, The Hague
Ministerie Van Defensie
Netherlands, Utrecht
University Medical Center Utrecht
Gillespie, Charles F.
United States, Atlanta
Emory University
Uka, Afërdita Goçi
Serbia, Pristina
University Clinical Center of Kosovo
Gordon, Scott D.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Guffanti, Guia
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Hammamieh, Rasha
United States, Fort Detrick
U.s. Army Medical Research and Development Command
Harnal, Supriya
United States, Cambridge
Massachusetts Institute of Technology
Hauser, Michael A.
United States, Durham
Duke University
Heath, Andrew Christopher
United States, St. Louis
Washington University School of Medicine in St. Louis
Hemmings, Sian Megan Joanna
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Hougaard, David Michael
Denmark, Copenhagen
Statens Serum Institut
Jakovljević, Miro
Croatia, Zagreb
Kbc Zagreb
Jett, Marti
United States, Fort Detrick
U.s. Army Medical Research and Development Command
Johnson, Eric Otto
United States, Research Triangle Park
Rti International
Jones, Ian Richard G.
United Kingdom, Cardiff
Cardiff University
Jovanović, Tanja
United States, Atlanta
Emory University
Qin, Xuejun
United States, Durham
Duke University
Junglen, Angela G.
United States, Kent
Kent State University
Karstoft, Karen Inge
Denmark, Copenhagen
Københavns Universitet
Kaufman, Milissa L.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Kessler, Ronald C.
United States, Boston
Harvard Medical School
Khan, Alaptagin
United States, Belmont
Mclean Hospital
United States, Boston
Harvard Medical School
Kimbrel, Nathan A.
United States, Durham
Duke University
United States, Durham
Durham va Medical Center
King, Anthony P.J.
United States, Ann Arbor
University of Michigan Medical School
Koen, Nastassja
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Kranzler, Henry R.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
United States
Va Medical Center
Kremen, William S.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Lawford, Bruce Robert
Australia, Brisbane
Queensland University of Technology
Lebois, Lauren A.M.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Lewis, Catrin E.
United Kingdom, Cardiff
Cardiff University
Linnstaedt, Sarah D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lori, Adriana
United States, Atlanta
Emory University
Lugonja, Božo
United Kingdom, Cardiff
Cardiff University
Luykx, Jurjen Justin
Netherlands, Utrecht
University Medical Center Utrecht
Lyons, Michael J.
United States, Boston
Boston University
Maples-Keller, Jessica L.
United States, Atlanta
Emory University
Marmar, Charles Raymond
United States, New York
Nyu Grossman School of Medicine
Martin, Alicia R.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Martin, Nicholas G.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Maurer, Douglas M.
United States, Arlington
Association of the United States Army
Mavissakalian, Matig R.
United States, Cleveland
University Hospitals Case Medical Center
McFarlane, Alexander Cowell
Australia, Adelaide
The University of Adelaide
McGlinchey, Regina E.
Unknown Affiliation
McLaughlin, Katie A.
United States, Cambridge
Harvard University
McLean, Samuel A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mehta, Divya
Australia, Brisbane
Queensland University of Technology
Milberg, William P.
Unknown Affiliation
Miller, Mark W.
United States, West Roxbury
Va Boston Healthcare System
Morey, Rajendra A.
United States, Durham
Duke University
Morris, Charles Phillip
Australia, Brisbane
Queensland University of Technology
Mors, Ole N.
Denmark, Aarhus
Aarhus Universitetshospital
Mortensen, Preben Bo
Denmark, Aarhus
Aarhus Universitet
Neale, Benjamin M.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Nordentoft, Merete
Denmark, Copenhagen
Københavns Universitet
O'Donnell, Meaghan L.
Australia, Melbourne
University of Melbourne
Orcutt, Holly K.
United States, Dekalb
Northern Illinois University
Panizzon, Matthew S.
United States, La Jolla
University of California, San Diego
Peverill, Matthew
United States, Seattle
University of Washington
Pietrzak, Robert H.
United States, New Haven
Yale School of Medicine
United States, Washington, D.c.
U.s. Department of Veterans Affairs
Rice, John P.
United States, St. Louis
Washington University School of Medicine in St. Louis
Ripke, Stephan
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
General Electric Company
Risbrough, Victoria B.
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Roberts, Andrea L.
United States, Boston
Harvard T.h. Chan School of Public Health
Rothbaum, Alex O.
United States, Cleveland
Case Western Reserve University
Rothbaum, Barbara Olasov
United States, Atlanta
Emory University
Roy-Byrne, Peter P.
United States, Seattle
University of Washington
Ruggiero, Kenneth J.
United States, Charleston
Medical University of South Carolina
Rutten, Bart PF F.
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Saccone, Nancy L.
United States, St. Louis
Washington University School of Medicine in St. Louis
Sánchez, Sixto E.
Peru, Lima
Universidad Peruana de Ciencias Aplicadas
Schijven, Dick
Netherlands, Utrecht
University Medical Center Utrecht
Seedat, Soraya
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Seligowski, Antonia V.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Sheerin, Christina M.
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Silove, Derrick M.
Australia, Sydney
Unsw Sydney
Smith, Alicia K.
United States, Atlanta
Emory University
Smoller, Jordan Wassertheil
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Sponheim, Scott R.
United States, Minneapolis
Va Midwest Health Care Network
United States, Minneapolis
University of Minnesota Twin Cities
Stein, Dan J.
South Africa, Cape Town
Sa Mrc Unit on Risk and Resilience in Mental Disorders
Sumner, Jennifer A.
United States, New York
Columbia University Irving Medical Center
Teicher, Martin Hersch
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Thompson, Wesley Kurt
United States, La Jolla
University of California, San Diego
Norway, Oslo
Oslo Universitetssykehus
Uddin, Monica
United States, Tampa
University of South Florida Health
Ursano, Robert J.
United States, Bethesda
Uniformed Services University of the Health Sciences
van den Heuvel, Leigh Luella
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Van Hooff, Miranda L.
Australia, Adelaide
The University of Adelaide
Vermetten, E. H.G.J.M.
United States, New York
Nyu Grossman School of Medicine
Netherlands, Leiden
Leids Universitair Medisch Centrum
Vinkers, Christiaan H.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Voisey, J.
Australia, Brisbane
Queensland University of Technology
Wang, Yunpeng
Norway, Oslo
Oslo Universitetssykehus
Werge, Thomas M.
Denmark, Copenhagen
Københavns Universitet
Williams, Michelle A.
United States, Boston
Harvard T.h. Chan School of Public Health
Winternitz, Sherry R.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Wolf, Christiane
Germany, Wurzburg
Universitätsklinikum Würzburg
Wolf, Erika J.
United States, West Roxbury
Va Boston Healthcare System
Wolff, Jonathan D.
United States, Belmont
Mclean Hospital
Yehuda, Rachel
United States, New York
Icahn School of Medicine at Mount Sinai
United States
Va Medical Center
Young, Ross Mc Donald
Australia, Brisbane
Queensland University of Technology
Zhao, Hongyu
United States, New Haven
Yale University
Zoellner, Lori A.
United States, Seattle
University of Washington
Liberzon, Israel
United States, Ann Arbor
University of Michigan Medical School
Ressler, Kerry James
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
United States, Atlanta
Emory University
Haas, Magali
Unknown Affiliation
Koenen, Karestan Chase
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 338
Authors: 166
Affiliations: 83
Identifiers
Doi:
10.1038/s41467-019-12576-w
ISSN:
20411723
Research Areas
Genetics And Genomics
Mental Health
Study Design
Cohort Study
Study Approach
Systematic review
Participants Gender
Male