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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Limited immunogenicity of HIV CD8
+
T-cell epitopes in acute clade C virus infection
Journal of Infectious Diseases, Volume 204, No. 5, Year 2011
Notification
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Description
Background. Human immunodeficiency virus type 1 (HIV-1) - specific CD8+ responses contribute to the decline in acute peak viremia following infection. However, data on the relative immunogenicity of CD8+ T-cell epitopes during and after acute viremia are lacking. Methods. We characterized CD8+ T-cell responses in 20 acutely infected, antiretroviral-naive individuals with HIV-1 subtype C infection using the interferon-c enzyme-linked immunosorbent spot assay. Eleven of these had not fully seroconverted at the time of analysis. Viruses from plasma were sequenced within defined cytotoxic T-lymphocyte (CTL) cell epitopes for selected subjects. Results. At approximately 28 days after estimated initial infection, CD8+ T-cell responses were directed against an average of 3 of the 410 peptides tested (range, 0-6); 2 individuals had no detectable responses at this time. At 18 weeks, the average number of peptides targeted had increased to 5 (range 0-11). Of the 56 optimal Gag CTL epitopes sequenced, 31 were wild-type in the infecting viruses, but only 11 of 31 elicited measurable CD8+ T-cell responses. Conclusions. These data demonstrate that the majority of CD8+ responses are not elicited during acute HIV infection despite the presence of the cognate epitope in the infecting strain. There is a need to define factors that influence lack of induction of effective immune responses and the parameters that dictate immunodominance in acute infection. © The Author 2011.
Authors & Co-Authors
Radebe, Mopo
South Africa, Durban
The Nelson R. Mandela Medical School
Nair, Kriebashnie S.
South Africa, Durban
The Nelson R. Mandela Medical School
Chonco, Fundisiwe M.
South Africa, Durban
The Nelson R. Mandela Medical School
Bishop, Karen S.
South Africa, Durban
The Nelson R. Mandela Medical School
Wright, Jaclyn K.
South Africa, Durban
The Nelson R. Mandela Medical School
Van Stok, Mary Der
South Africa, Durban
The Nelson R. Mandela Medical School
Bassett, Ingrid V.
United States, Cambridge
Harvard University
Mncube, Zenele
South Africa, Durban
The Nelson R. Mandela Medical School
Altfeld, Marcus A.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Harvard University
Walker, Bruce D.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Harvard University
United States, Chevy Chase
Howard Hughes Medical Institute
Ndung'u, Thumbi P.
South Africa, Durban
The Nelson R. Mandela Medical School
United States, Cambridge
Harvard University
Statistics
Citations: 37
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jir394
ISSN:
00221899
Research Areas
Infectious Diseases