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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cytoadherence in paediatric malaria: ABO blood group, CD36, and ICAM1 expression and severe Plasmodium falciparum infection
British Journal of Haematology, Volume 159, No. 2, Year 2012
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Description
As a leading cause of childhood mortality worldwide, selection pressure by Plasmodium falciparum continues to shape the human genome. Severe disturbances within the microcirculation result from the adhesion of infected erythrocytes to host receptors on monocytes, platelets, and endothelium. In this prospective study, we compared expression of all major host cytoadhesion receptors among Ugandan children presenting with uncomplicated malaria (n = 1078) versus children with severe malaria (n = 855), including cerebral malaria (n = 174), severe anaemia (n = 522), and lactic acidosis (n = 154). We report a significant survival advantage attributed to blood group O and increased monocyte expression of CD36 and ICAM1 (CD54). The high case fatality rate syndromes of cerebral malaria and lactic acidosis were associated with high platelet CD36 expression and thrombocytopenia, and severe malaria anaemia was characterized by low ICAM1 expression. In a logistic regression model of disease severity, odds ratios for the mitigating effects of blood group O, CD36, and ICAM1 phenotypes were greater than that of sickle haemoglobin. Host genetic adaptations to Plasmodium falciparum suggest new potential malaria treatment strategies. © 2012 Blackwell Publishing Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3470923/bin/bjh0159-0223-SD1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3470923/bin/bjh0159-0223-SD2.png
Authors & Co-Authors
Cserti-Gazdewich, Christine M.
Unknown Affiliation
Dhabangi, Aggrey
Unknown Affiliation
Musoke, Charles
Unknown Affiliation
Ssewanyana, Isaac
Unknown Affiliation
Ddungu, Henry D.
Unknown Affiliation
Nakiboneka-Ssenabulya, Deborah L.
Unknown Affiliation
Nabukeera-Barungi, Nicolette
Unknown Affiliation
Mpimbaza, Arthur
Unknown Affiliation
Dzik, Walter Sunny
Unknown Affiliation
Statistics
Citations: 35
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1111/bjh.12014
ISSN:
00071048
e-ISSN:
13652141
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study