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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
IspC as target for antiinfective drug discovery: Synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters
Journal of Medicinal Chemistry, Volume 56, No. 20, Year 2013
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Description
The emergence and spread of multidrug-resistant pathogens are widely believed to endanger human health. New drug targets and lead compounds exempt from cross-resistance with existing drugs are urgently needed. We report on the synthesis and properties of "reverse" thia analogs of fosmidomycin, which inhibit the first committed enzyme of a metabolic pathway that is essential for the causative agents of tuberculosis and malaria but is absent in the human host. Notably, IspC displays a high level of enantioselectivity for an α-substituted fosmidomycin derivative. © 2013 American Chemical Society.
Authors & Co-Authors
Kunfermann, Andrea
Germany, Munich
Munich Center for Integrated Protein Science
Lienau, Claudia
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Illarionov, Boris A.
Germany, Hamburg
Universität Hamburg
Held, Jana
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gräwert, Tobias W.
Germany, Hamburg
Universität Hamburg
Behrendt, Christoph T.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Hähn, Saskia
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Eisenreich, Wolfgang
Germany, Munich
Munich Center for Integrated Protein Science
Riederer, Ulrich
Germany, Hamburg
Universität Hamburg
Mordmüller, Benjamin G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Bacher, Adelbert
Germany, Hamburg
Universität Hamburg
Fischer, Markus
Germany, Hamburg
Universität Hamburg
Groll, Michael
Germany, Munich
Munich Center for Integrated Protein Science
Kurz, Thomas
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Statistics
Citations: 36
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1021/jm4012559
ISSN:
00222623
Research Areas
Infectious Diseases
Noncommunicable Diseases