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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Biological Markers Associated with Prolonged Survival in African Children Maternally Infected by the Human Immunodeficiency Virus Type 1
AIDS Research and Human Retroviruses, Volume 8, No. 4, Year 1992
Notification
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Description
Sixteen children over the age of 5 years (Group 1) have been identified out of 537 children infected by human immunodeficiency virus and born to HIV-infected mothers, in Kigali, Rwanda. They were followed up for 2 years and compared with 16 younger AIDS patients (Group 2) and with 16 age- and gender-matched HIV-1 seronegative children (Group 3). Fourteen Group 1 subjects had anti-HIV-1 IgM which persisted during the entire study period, in 11 cases directed to HIV-1 envelope proteins. In vitro, immortalization of B lymphocytes by the Epstein-Barr virus confirmed a high production of IgM to envelope proteins. All these patients had anti-p 17 IgG which was not observed in 7 patients from Group 2. All 16 children mounted significant titers of neutralizing antibodies to HTLVIIIB, and, in 8 patients tested, against two other HIV-1 strains, RII and MN. HIV-1-specific major histocompatibility complex (MHC)-restricted cytotoxic T cells were demonstrated in 3 of 5 of the subgroup who were tested. Prolonged survival over 5 years in children with maternally acquired HIV-1 infection is associated with a high titer of neutralizing antibodies, a persistent production of IGM to HIV-1 envelope proteins and of IgG to p 17. © 1992, Mary Ann Liebert, Inc. All rights reserved.
Authors & Co-Authors
van de Perre, Philippe
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Lepage, Philippe
Saudi Arabia
Centre Hospitalier de Kigali
Simonon, Arlette
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Des̀granges, Claude
France, Paris
Inserm
Hitimana, Déo Gratias
Saudi Arabia
Centre Hospitalier de Kigali
Bazubagira, Anatholie
Saudi Arabia
Centre Hospitalier de Kigali
van Goethem, Christiaan
Saudi Arabia
Centre Hospitalier de Kigali
Kleinschmidt, Andrea
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Bex, Françoise
Belgium, Brussels
Free Universities of Brussels
Broliden, Kristina
Sweden, Stockholm
Karolinska Institutet
Erfle, Volker F.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Gotch, Frances M.
United Kingdom, Oxford
John Radcliffe Hospital
Burny, Arséne
Belgium, Brussels
Free Universities of Brussels
Statistics
Citations: 19
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1089/aid.1992.8.435
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Rwanda