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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Content validity of symptom-based measures for diabetic, chemotherapy, and HIV peripheral neuropathy
Muscle and Nerve, Volume 55, No. 3, Year 2017
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Description
Introduction: No treatments for axonal peripheral neuropathy are approved by the United States Food and Drug Administration (FDA). Although patient- and clinician-reported outcomes are central to evaluating neuropathy symptoms, they can be difficult to assess accurately. The inability to identify efficacious treatments for peripheral neuropathies could be due to invalid or inadequate outcome measures. Methods: This systematic review examined the content validity of symptom-based measures of diabetic peripheral neuropathy, HIV neuropathy, and chemotherapy-induced peripheral neuropathy. Results: Use of all FDA-recommended methods to establish content validity was only reported for 2 of 18 measures. Multiple sensory and motor symptoms were included in measures for all 3 conditions; these included numbness, tingling, pain, allodynia, difficulty walking, and cramping. Autonomic symptoms were less frequently included. Conclusions: Given significant overlap in symptoms between neuropathy etiologies, a measure with content validity for multiple neuropathies with supplemental disease-specific modules could be of great value in the development of disease-modifying treatments for peripheral neuropathies. Muscle Nerve 55: 366–372, 2017. © 2016 Wiley Periodicals, Inc.
Authors & Co-Authors
Gewandter, Jennifer S.
United States, Rochester
University of Rochester
Cavaletti, Guido Angelo
Italy, Milan
Università Degli Studi Di Milano-bicocca
Dworkin, Robert H.
United States, Rochester
University of Rochester
Herrmann, David N.
United States, Rochester
University of Rochester
McArthur, Justin Charles
United States, Baltimore
Johns Hopkins University
Mcdermott, Michael P.
United States, Rochester
University of Rochester
Reeve, Bryce B.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Smith, Albert Gordon
United States, Salt Lake City
The University of Utah
Turk, Dennis C.
United States, Seattle
University of Washington
Vinik, Aaron I.
United States, Norfolk
Eastern Virginia Medical School
Freeman, Roy L.
United States, Boston
Harvard Medical School
Statistics
Citations: 18
Authors: 11
Affiliations: 10
Identifiers
Doi:
10.1002/mus.25264
ISSN:
0148639X
Research Areas
Cancer
Food Security
Health System And Policy
Infectious Diseases
Study Approach
Systematic review