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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
Proceedings of the National Academy of Sciences of the United States of America, Volume 104, No. 5, Year 2007
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Description
Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and repair after ischemic injury. Sfrp2 is known to modulate Wnt signaling, and we demonstrate that cardiomyocytes treated with secreted frizzled related protein increase cellular β-catenin and up-regulate expression of antiapoptotic genes. These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease. © 2007 by The National Academy of Sciences of the USA.
Authors & Co-Authors
Mirotsou, Maria
United States, Durham
Duke University Medical Center
Gnecchi, Massimiliano
United States, Durham
Duke University Medical Center
Dzau, Victor J.
United States, Durham
Duke University Medical Center
Statistics
Citations: 472
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1073/pnas.0610024104
ISSN:
00278424
Research Areas
Cancer
Noncommunicable Diseases
Violence And Injury