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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Origin and diversification of the human parasite Schistosoma mansoni
Molecular Ecology, Volume 14, No. 12, Year 2005
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Description
Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country. © 2005 Blackwell Publishing Ltd.
Authors & Co-Authors
Morgan, Jess A.T.
United States, Albuquerque
The University of new Mexico
DeJong, Randall J.
United States, Albuquerque
The University of new Mexico
Adeoye, Grace O.
Nigeria, Lagos
University of Lagos
Ansa, Ebenezer D.O.
Ghana, Accra
Csir - Water Research Institute Ghana
Barbosa, C. S.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brémond, Philippe
Madagascar, Antananarivo
Institut de Recherche Pour le Developpement Antananarivo
Cesari, Italo M.
Venezuela, Caracas
Instituto Venezolano de Investigaciones Cientificas, Centro de Microbiologia y Biologia Celular
Charbonnel, Nathalie
France, Montferrier-sur-lez
Centre de Biologie Pour la Gestion Des Populations Cbgp
Corrêa, Lygia R.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Coulibaly, Godefroy
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
D’Andrea, Paulo Sergio
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
de Souza, Cecília Pereira S.
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Doenhoff, Michael J.
United Kingdom, Bangor
Bangor University
File, Sharon K.
Puerto Rico, San Juan
Universidad de Puerto Rico
Idris, M. A.
Oman, Muscat
Sultan Qaboos University
Incani, R. Nino
Venezuela, Valencia
Universidad de Carabobo
Jarne, Philippe
France, Paris
Cnrs Centre National de la Recherche Scientifique
Karanja, Diana M.Sabwa
Kenya, Nairobi
Kenya Medical Research Institute
Kazibwe, Francis
Uganda, Kampala
Uganda Ministry of Health
Kpikpi, John E.K.
Ghana, Accra
University of Ghana
Lwambo, Nicholas J.S.
Tanzania, Tanga
National Institute for Medical Research Tanga
Mabaye, Amadou
Senegal, St Louis
Programme de Lutte Controle la Bilharziose
Magalhäes, Luiz Augusto
Brazil, Campinas
Universidade Estadual de Campinas
Makundi, Asanteli E.
Tanzania, Dar es Salaam
Open University of Tanzania
Moné, Hélène
France, Perpignan
Université de Perpignan Via Domitia
Mouahid, Gabriel
France, Perpignan
Université de Perpignan Via Domitia
Muchemi, Gerald Mwangi
Kenya, Nairobi
University of Nairobi
Mungai, Benjamin N.
Kenya, Nairobi
Kenya Medical Research Institute
Sène, Mariama
France, Marseille
Ird Institut de Recherche Pour le Developpement
Southgate, Vaughan Robert
United Kingdom, South Kensington
Wolfson Wellcome Biomedical Laboratories
Tchuem Tchuenté, Louis Albert
Cameroon, Yaounde
Centre for Schistosomiasis and Parasitology
Thèron, André É.
France, Perpignan
Université de Perpignan Via Domitia
Yousif, Fouad
Egypt, Giza
Theodor Bilharz Research Institute
Zanotti-Magalhães, Eliana Maria
Senegal, St Louis
Programme de Lutte Controle la Bilharziose
Mkoji, Gerald M.
Kenya, Nairobi
Kenya Medical Research Institute
Loker, Eric Samuel
United States, Albuquerque
The University of new Mexico
Statistics
Citations: 127
Authors: 36
Affiliations: 26
Identifiers
Doi:
10.1111/j.1365-294X.2005.02709.x
ISSN:
09621083
e-ISSN:
1365294X
Research Areas
Cancer
Genetics And Genomics
Study Locations
Madagascar