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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-2 does not protect against HIV-1 infection in a rural community in Guinea-Bissau
AIDS, Volume 15, No. 17, Year 2001
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Description
Objective: To examine the putative protective effect of HIV-2 infection against subsequent HIV-1 infection. Design: Retrospective analysis of data from two cross-sectional surveys in the same community. Methods: Two surveys between 1989 and 1998 in a rural area in northwestern Guinea-Bissau provided data from residents aged 15-59 years. HIV testing was done in the first survey. In the second survey, tests were made for both HIV and syphilis, and data on sociodemographic factors and sexual behaviour, including commercial sex work, were gathered. Qualitative polymerase chain reaction amplification of HIV-1 and HIV-2 viral DNA was performed on serologically dually reactive samples. Results: Of the 2276 eligible adult villagers initially tested, 60% (1360) provided a second sample. Of 110 HIV-2-infected subjects, 17 became additionally infected with HIV-1 [incidence rate (IR), 26.3/1000 person-years observation]. Of the 1250 HIV-seronegative subjects, 24 became infected with HIV-1 (IR, 2.8/1000 person-years observation). The incidence rate ratio (IRR), comparing the incidence rate in HIV-2-infected people with the rate in HIV-seronegative subjects, was > 1 in all three 'risk groups': men, female commercial sex workers, and other women. The overall estimate of the IRR, adjusted for age group and risk group, was 3.24 (confidence interval, 1.5-7.1). Conclusions: There was no protective effect of HIV-2 in this population. HIV-2 cannot be regarded as a vaccine, but, instead, may be a risk factor for HIV-1 infection. © 2001 Lippincott Williams & Wilkins.
Authors & Co-Authors
Schim-van der Loeff, Maarten Franciscus
Unknown Affiliation
Aaby, Peter
Unknown Affiliation
Vincent, Tim
Unknown Affiliation
Awasana, Akum Aveika
Unknown Affiliation
da Costa, Carlos Araújo
Unknown Affiliation
Pembrey, Lucy Jane
Unknown Affiliation
Dias, Francisco
Unknown Affiliation
Harding, Elizabeth
Unknown Affiliation
Weiss, Helen Anne
Unknown Affiliation
Whittle, Hilton C.
Unknown Affiliation
Statistics
Citations: 40
Authors: 10
Identifiers
Doi:
10.1097/00002030-200111230-00012
ISSN:
02699370
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Qualitative
Quantitative
Study Locations
Guinea
Guinea-Bissau
Participants Gender
Male
Female