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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efflux inhibition with verapamil potentiates bedaquiline in mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy, Volume 58, No. 1, Year 2014
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Description
Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs. © 2014, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Gupta, Shashank
United States, Baltimore
Johns Hopkins University
United States, Chevy Chase
Howard Hughes Medical Institute
Cohen, Keira A.
United States, Boston
Brigham and Women's Hospital
South Africa, Durban
Africa Health Research Institute
Winglee, Kathryn
United States, Baltimore
Johns Hopkins University
Maiga, Mamoudou
United States, Baltimore
Johns Hopkins University
Mali, Bamako
University of Bamako
Diarra, Bassirou
Mali, Bamako
University of Bamako
Bishai, William R.
United States, Baltimore
Johns Hopkins University
United States, Chevy Chase
Howard Hughes Medical Institute
South Africa, Durban
Africa Health Research Institute
Statistics
Citations: 133
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1128/AAC.01462-13
ISSN:
00664804
e-ISSN:
10986596