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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Nature Medicine, Volume 29, No. 10, Year 2023
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Description
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Tobias, Deirdre K.
United States, Boston
Harvard Medical School
United States, Boston
Harvard T.h. Chan School of Public Health
Merino, Jordi
Denmark, Copenhagen
Københavns Universitet
United States, Boston
Massachusetts General Hospital
Aiken, Catherine E.M.
United Kingdom, Cambridge
Rosie Hospital
United Kingdom, Cambridge
University of Cambridge
Benham, Jamie L.
Canada, Calgary
University of Calgary
Bodhini, Dhanasekaran
India, Chennai
Madras Diabetes Research Foundation
Colclough, Kevin C.
United Kingdom, Exeter
University of Exeter Medical School
Gaillard, Romy
Netherlands, Rotterdam
Erasmus Mc
Kahkoska, Anna R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lim, Lee Ling
Malaysia, Kuala Lumpur
Universiti Malaya
Hong Kong, Hong Kong
Asia Diabetes Foundation
Hong Kong, Hong Kong
Chinese University of Hong Kong
Patel, Kashyap A.
United Kingdom, Exeter
University of Exeter Medical School
Takele, Wubet Worku
Australia, Clayton
Monash University
Tam, Claudia Ha Ting
Hong Kong, Hong Kong
Chinese University of Hong Kong
Bonham, Maxine P.
Australia, Clayton
Monash University
Chikowore, Tinashe
United States, Boston
Harvard Medical School
South Africa, Tygerberg
South African Medical Research Council
United States, Boston
Channing Division of Network Medicine
South Africa, Johannesburg
University of the Witwatersrand
Clemmensen, Christoffer
Denmark, Copenhagen
Københavns Universitet
Dabelea, Dana M.
United States, Aurora
University of Colorado Anschutz Medical Campus
Goodarzi, Mark O.
United States, Los Angeles
Cedars-sinai Medical Center
Hansen, Torben
Denmark, Copenhagen
Københavns Universitet
Ismail, Heba M.
United States, Indianapolis
Indiana University School of Medicine
Jones, Angus G.
United Kingdom, Exeter
University of Exeter Medical School
United Kingdom, Exeter
University of Exeter
Leong, Aaron
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Libman, Ingrid M.
United States, Pittsburgh
Upmc Children’s Hospital of Pittsburgh
Lowe, William L.
United States, Chicago
Northwestern University Feinberg School of Medicine
Motala, Ayesha A.
South Africa, Durban
University of Kwazulu-natal
Önengüt-Gümüşcü, Suna
United States, Charlottesville
University of Virginia
Pazmino, Sofia
Belgium, Leuven
Ku Leuven
Petrie, John R.
United Kingdom, Glasgow
University of Glasgow
Powe, Camille E.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Ray, Debashree
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Scholtens, Denise M.
United States, Chicago
Northwestern University Feinberg School of Medicine
Selvin, Elizabeth
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Sheu, Wayne Huey Herng
Taiwan, Zhunan
National Health Research Institutes Taiwan
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Taiwan, Taipei
Taipei Veterans General Hospital
Speake, Cate
United States, Seattle
Benaroya Research Institute at Virginia Mason
Stanislawski, Maggie A.
United States, Aurora
University of Colorado Anschutz Medical Campus
Steenackers, Nele
Belgium, Leuven
Ku Leuven
Steck, Andrea K.
United States, Denver
Barbara Davis Center for Childhood Diabetes
Stefan, Norbert
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Munich
Institut Für Diabetesforschung
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Ukke, Gebresilasea Gendisha
Australia, Clayton
Monash University
van der Schueren, Bart
Belgium, Leuven
Ku Leuven
Belgium, Leuven
Ku Leuven– University Hospital Leuven
White, Sara Loiuse
United Kingdom, London
King's College London
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Zhang, Yingchai
Hong Kong, Hong Kong
Chinese University of Hong Kong
Zhou, Shaojia
Australia, Adelaide
The University of Adelaide
Beltrand, Jacques
France, Paris
Inserm
France, Paris
Hôpital Necker Enfants Malades
Polak, Michel
France, Paris
Inserm
France, Paris
Hôpital Necker Enfants Malades
de Franco, Elisa
United Kingdom, Exeter
University of Exeter Medical School
Flanagan, Sarah E.
United Kingdom, Exeter
University of Exeter Medical School
Molnes, Janne
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Nakabuye, Mariam
Denmark, Copenhagen
Københavns Universitet
Njolstad, Pãl Rasmus
Norway, Bergen
Universitetet I Bergen
Norway, Bergen
Haukeland Universitetssjukehus
Saint-Martin, Cećile
France, Paris
Sorbonne Université
Zhang, Cuilin
Singapore, Singapore City
National University of Singapore
Auh, Sungyoung
United States, Bethesda
National Institutes of Health Nih
de Souza, Russell J.
Canada, Hamilton
Population Health Research Institute, Ontario
Canada, Hamilton
Mcmaster University
Mekonnen, Eskedar Getie
Ethiopia, Gondar
University of Gondar
Belgium, Antwerpen
Universiteit Antwerpen
Nolan, John J.
Ireland, Dublin
Trinity College Dublin
Ireland, Wexford
Wexford General Hospital
Brown, Rebecca J.
United States, Bethesda
National Institutes of Health Nih
Billings, Liana K.
United States, Evanston
Northshore University Healthsystem
United States, Chicago
The University of Chicago
Florez, Jose C.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Gloyn, Anna L.
United States, Palo Alto
Stanford University
Gomez, Maria Fernanda Rojas
Sweden, Malmo
Lund University Diabetes Centre
Denmark, Aarhus
Aarhus Universitet
Gottlieb, Peter A.
United States, Denver
Barbara Davis Center for Childhood Diabetes
Hirsch, Irl B.
United States, Seattle
University of Washington School of Medicine
Hivert, Marie France
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Canada, Sherbrooke
Université de Sherbrooke
Kwak, Soo-heon
South Korea, Seoul
Seoul National University Hospital
Ma, Ronald Ching Wan
Hong Kong, Hong Kong
Chinese University of Hong Kong
Meigs, James B.
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
Mohan, Viswanathan Krishna
India, Chennai
Madras Diabetes Research Foundation
Murphy, Rinki P.
New Zealand, Auckland
The University of Auckland
New Zealand, Auckland
Auckland Diabetes Centre
New Zealand, Auckland
Health new Zealand
Owen, Katharine R.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Ozanne, Susan E.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Pearson, Ewan Robert
United Kingdom, Dundee
University of Dundee
Perng, Wei
United States, Aurora
University of Colorado Anschutz Medical Campus
Pop-Busui, Rodica
United States, Ann Arbor
University of Michigan, Ann Arbor
Pratley, Richard E.
United States, Orlando
Adventhealth Translational Research Institute
Redman, Leanne Maree
United States, Baton Rouge
Pennington Biomedical Research Center
Redondo, María José
United States, Houston
Baylor College of Medicine
United States, Houston
Texas Children's Hospital
Reynolds, Rebecca M.
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Semple, Robert K.
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
United Kingdom, Edinburgh
The University of Edinburgh
Sherr, Jennifer L.
United States, New Haven
Yale School of Medicine
Tuomi, Tiinamaija
Finland, Helsinki
Helsinki University Hospital
Finland, Helsinki
Folkhälsan
Finland, Helsinki
Helsingin Yliopisto
Udler, Miriam S.
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Vesco, Kimberly K.
United States, Oakland
Kaiser Permanente
Rich, Stephen S.
United States, Charlottesville
University of Virginia
Franks, Paul W.
United States, Boston
Harvard T.h. Chan School of Public Health
Sweden, Malmo
Lund University Diabetes Centre
United Kingdom, Oxford
University of Oxford
Denmark, Hellerup
Novo Nordisk Foundation
Statistics
Citations: 28
Authors: 84
Affiliations: 137
Identifiers
Doi:
10.1038/s41591-023-02502-5
ISSN:
10788956
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases