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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cardiovascular diseases and erectile dysfunction: The two faces of the coin of androgen deficiency
Andrologia, Volume 43, No. 1, Year 2011
Notification
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Description
Traditionally, clinical conditions synonymous with the ageing male included cardiovascular disease (CVD), type 2 diabetes mellitus (DM) and sexual dysfunction, and were widely regarded as independent clinical entities. Over the last decade, interrelationship of clinical conditions has been convincingly demonstrated. Declining testosterone levels in the elderly, once regarded as an academic endocrinological question, appear to be central to the listed pathologies. It is now clear that erectile dysfunction is an expression of endothelial dysfunction. Testosterone deficiency is associated with an increased incidence of CVD and DM. The latter is often the sequel of the metabolic syndrome. Visceral obesity, a pivotal characteristic of the metabolic syndrome, suppresses the hypothalamic-pituitary-testicular axis leading to diminished testosterone production. Conversely, substantial androgen deficiency leads to signs and symptoms of metabolic syndrome. It is erroneous not to include testosterone measurements in the progress of the CVD, DM and erectile dysfunction. These conditions correlate strongly with testosterone deficiency. © 2010 Blackwell Verlag GmbH.
Authors & Co-Authors
Yassin, Aksam A.
Germany, Hamburg
Segeberger Kliniken
Akhras, F.
United Kingdom, London
Cromwell Hospital
United Kingdom, London
Cardiac and Medical Healthcare Services
El-Sakka, Ahmed I.
Egypt, Ismailia
Faculty of Medicine
Saad, Farid
Germany, Berlin
Scientific Affairs Men's Healthcare
United Arab Emirates, Ajman
Gulf Medical University
Statistics
Citations: 28
Authors: 4
Affiliations: 6
Identifiers
Doi:
10.1111/j.1439-0272.2009.01021.x
ISSN:
03034569
e-ISSN:
14390272
Research Areas
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Male