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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evolution of mortality over time in patients receiving mechanical ventilation
American Journal of Respiratory and Critical Care Medicine, Volume 188, No. 2, Year 2013
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Description
Rationale: Baseline characteristics and management have changed over time in patients requiring mechanical ventilation; however, the impact of these changes on patient outcomes is unclear. Objectives: To estimate whether mortality in mechanically ventilated patients has changed over time. Methods: Prospective cohort studies conducted in 1998, 2004, and 2010, including patients receiving mechanical ventilation for more than 12 hours in a 1-month period, from 927 units in 40 countries. To examine effects over time on mortality in intensive care units, we performed generalized estimating equation models. Measurements and Main Results: We included 18,302 patients. The reasons for initiating mechanical ventilation varied significantly among cohorts. Ventilatory management changed over time (P < 0.001), with increased use of noninvasive positive-pressure ventilation (5% in 1998 to 14% in 2010), a decrease in tidal volume (mean 8.8 ml/kg actual body weight [SD = 2.1] in 1998 to 6.9 ml/kg [SD = 1.9] in 2010), and an increase in applied positive end-expiratory pressure (mean 4.2 cm H2O [SD= 3.8] in 1998 to 7.0 cm of H2O [SD= 3.0] in 2010). Crude mortality in the intensive care unit decreased in 2010 compared with 1998 (28 versus 31%; odds ratio, 0.87; 95%confidence interval, 0.80-0.94), despite a similar complication rate. Hospital mortality decreased similarly. After adjusting for baseline and management variables, this difference remained significant (odds ratio, 0.78; 95%confidence interval, 0.67-0.92). Conclusions: Patient characteristics and ventilation practices have changed over time, and outcomes ofmechanically ventilated patients have improved. Copyright © 2013 by the American Thoracic Society.
Authors & Co-Authors
Esteban, Andrés
Spain, Getafe
Hospital Universitario de Getafe
Frutos-Vivar, Fernando
Spain, Getafe
Hospital Universitario de Getafe
Muriel, A.
Spain, Madrid
Hospital Universitario Ramón y Cajal
Ferguson, Niall D.
Canada, Toronto
University of Toronto
Peñuelas, Óscar
Spain, Getafe
Hospital Universitario de Getafe
Abraira, Vićtor
Spain, Madrid
Hospital Universitario Ramón y Cajal
Raymondos, Konstantinos
Germany, Hannover
Hannover Medical School
Ríos, Fernando Gonçalves
Argentina, Buenos Aires
Hospital Nacional Professor Dr. Alejandro Posadas
Nín, Nicholas
Spain, Getafe
Hospital Universitario de Getafe
Apezteguía, Carlos J.
Argentina, Buenos Aires
Hospital Nacional Professor Dr. Alejandro Posadas
Violi, Damian A.
Argentina, Haedo
Hospital Interzonal General de Agudos Dr. Luis Güemes
Thille, Arnaud W.
France, Creteil
Hôpital Henri Mondor
Brochard, Laurent Jean
Switzerland, Geneva
Hôpitaux Universitaires de Genève
González, Marco A.
Colombia, Medellin
Universidad Pontificia Bolivariana
Villagómez, Asisclo Jesús
Mexico, Mexico
Instituto de Seguridad y Servicios Sociales de Los Trabajadores Del Estado - Issste
Hurtado, Javier L.
Uruguay, Montevideo
Hospital de Clinicas Dr. Manuel Quintela
Davies, Andrew R.
Australia, Clayton
Monash University
Du, Bin
China, Beijing
Peking Union Medical College Hospital
Maggiore, Salvatore Maurizio
Italy, Rome
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Pelosi, Paolo P.
Italy, Genoa
Scuola Di Scienze Mediche e Farmaceutiche, Università Degli Studi Di Genova
Soto, Luis
Chile, Santiago
Instituto Nacional Del Tórax
Tomicic F, Vinko
Chile, Santiago
Clínica Las Lilas
D'Empaire, Gabriel
Venezuela, Caracas
Hospital de Clínicas Caracas
Matamis, Dimitrios
Greece, Thessaloniki
Papageorgiou General Hospital
Abrouk, Fekri
Tunisia, Monastir
Chu Fattouma-bourguiba
Moreno, Rui Paulo
Portugal, Lisbon
Hospital de São José
AntonioSoares, Marco
Brazil, Belo Horizonte
Hospital Universitário São José
Arabi, Yaseen M.
Saudi Arabia, Riyadh
King Saud Bin Abdulaziz University for Health Sciences
Sandi, Freddy
Bolivia
Hospital Obrero No. 1
Jibaja, Manuel
Ecuador, Quito
Hospital Eugenio Espejo
Amin, Pravin R.
India, Mumbai
Bombay Hospital and Medical Research Centre
Koh, Younsuck
South Korea, Ulsan
University of Ulsan
Kuiper, Michaël A.
Netherlands, Leeuwarden
Medisch Centrum Leeuwarden
Bülow, Hans Henrik
Denmark, Holbak
Holbæk Sygehus
Zeggwagh, Amine Ali
Morocco, Agdal Rabat
Ibn Sina Hospital, Agdal Rabat
Anzueto, Antonio R.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Statistics
Citations: 549
Authors: 36
Affiliations: 31
Identifiers
Doi:
10.1164/rccm.201212-2169OC
ISSN:
1073449X
Research Areas
Health System And Policy
Study Design
Cohort Study
Case-Control Study