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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Penicillin Reactions in Patients With Severe Rheumatic Heart Disease: A Presidential Advisory From the American Heart Association
Journal of the American Heart Association, Volume 11, No. 5, Article e024517, Year 2022
Notification
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Description
Secondary antibiotic prophylaxis with regular intramuscular benzathine penicillin G (BPG) is the cornerstone of rheumatic heart disease management. However, there is a growing body of evidence that patients with rheumatic heart disease who have severe valvular heart disease with or without reduced ventricular function may be dying from cardiovascular compromise following BPG injections. This advisory responds to these concerns and is intended to: (1) raise awareness, (2) provide risk stratification, and (3) provide strategies for risk reduction. Based on available evidence and expert opinion, we have divided patients into low-and elevated-risk groups, based on symptoms and the severity of underlying heart disease. Patients with elevated risk include those with severe mitral stenosis, aortic stenosis, and aortic insuffiency; those with decreased left ventricular systolic dysfunction; and those with no symptoms. For these patients, we believe the risk of adverse reaction to BPG, specifically cardiovascular compromise, may outweigh its theoretical benefit. For patients with elevated risk, we newly advise that oral prophylaxis should be strongly considered. In addition, we advocate for a multifaceted strategy for vasovagal risk reduction in all patients with rheumatic heart disease receiving BPG. As current guidelines recommend, all low-risk patients without a history of penicillin allergy or anaphylaxis should continue to be prescribed BPG for secondary antibiotic prophylaxis. We publish this advisory in the hopes of saving lives and avoiding events that can have devastating effects on patient and clinician confidence in BPG. © 2022 The Authors. Published on behalf of the American Heart Association, Inc.,.
Authors & Co-Authors
Sanyahumbi, Amy E.Sims
Unknown Affiliation
Ali, Sulafa Khalid Mohamed
Unknown Affiliation
Benjamin, Ivor J.
Unknown Affiliation
Karthikeyan, Ganesan
Unknown Affiliation
Okello, Emmy S.
Unknown Affiliation
Sable, Craig Andrew
Unknown Affiliation
Taubert, Kathryn A.
Unknown Affiliation
Wyber, Rosemary
Unknown Affiliation
Zühlke, Liesl Joanna
Unknown Affiliation
Carapetis, Jonathan R.
Unknown Affiliation
Beaton, Andrea Zawacki
Unknown Affiliation
Statistics
Citations: 6
Authors: 11
Identifiers
Doi:
10.1161/JAHA.121.024517
ISSN:
20479980
Research Areas
Health System And Policy
Noncommunicable Diseases