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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Type 2 diabetes does not attenuate racial differences in coronary calcification
Diabetes Research and Clinical Practice, Volume 91, No. 1, Year 2011
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Description
Aims: Coronary artery calcification (CAC) is a strong predictor of atherosclerotic cardiovascular disease (CVD). Whites appear to have a higher prevalence of CAC than African-Americans (AAs), but it is unknown if type 2 diabetes, a major cardiovascular risk factor, attenuates this difference. We investigated the relationship of race and CAC in a sample of patients with type 2 diabetes without clinical CVD. Methods: Multivariable analyses of self-reported ethnicity and CAC scores, stratified by gender, in 861 subjects [32% AA, 66.9% male] with type 2 diabetes. Results: AA race was associated with lower CAC scores in age-adjusted models in males [Tobit ratio for AAs vs. Whites 0.14 (95% CI 0.08-0.24, p< 0.001)] and females [Tobit ratio 0.26 (95% CI 0.09-0.77, p= 0.015)]. This persisted in men after adjustment for traditional, metabolic and inflammatory risk factors, but adjustment for plasma triglycerides [0.48 (95% CI 0.15-1.49, p= 0.201)] and HOMA-IR [0.28 (95% CI 0.08-1.03, p= 0.055)] partially attenuated the association in women. Conclusions: Relative to African-Americans, White race is a strong predictor of CAC, even in the presence of type 2 diabetes. The relationship in women appears less robust possibly due to gender differences in metabolic risk factors. © 2010.
Authors & Co-Authors
Wade, Alisha N.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Fedyna, Sean
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Mehta, Nehal N.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
St. Clair, Caitlin
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Ginwala, Naeema
United States, Syracuse
Suny Upstate Medical University
Krishna, Rama K.
United States, Philadelphia
Pennsylvania Hospital
Qasim, Atif Nazier
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Braunstein, Seth
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Iqbal, Nayyar
United States
Va Medical Center
Schutta, Mark H.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Reilly, Muredach P.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Statistics
Citations: 11
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1016/j.diabres.2010.07.004
ISSN:
01688227
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male
Female