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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda
Journal of Infectious Diseases, Volume 198, No. 3, Year 2008
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Description
Background. Malaria risk may be heterogeneous in urban areas of Africa. Identifying those at highest risk for malaria may lead to more targeted approaches to malaria control. Methods. A representative sample of 558 children aged 1-10 years were recruited from a census population in a single parish of Kampala and followed up for 2 years. Malaria was diagnosed when a child presented with a new episode of fever and a thick blood smear positive for parasites. Multivariate analysis was used to identify independent predictors of malaria incidence. Results. A total of 695 episodes of uncomplicated malaria were diagnosed after 901 person years of follow-up. Sickle cell trait (relative risk [RR], 0.68 [95% confidence interval {CI}, 0.52-0.90]), glucose-6-phosphate dehydrogenase deficiency in female children (RR, 0.48 [95% CI, 0.31-0.75]), and use of an insecticide-treated bed net (RR, 0.52 [95% CI, 0.32-0.83]) were associated with a lower risk of malaria. The distance of the subject's residence from a swamp bordering the parish showed a strong "dose-response" relationship; living in the swamp was the strongest predictor of malaria risk (RR, 3.94 [95% CI, 2.61-5.97]). Conclusion. Malaria incidence was highly heterogeneous in this urban cohort of children. Malaria control interventions in urban areas should target populations living in pockets of high malaria risk. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Clark, Tamara D.
Unknown Affiliation
Greenhouse, Bryan R.
Unknown Affiliation
Njama-Meya, Denise
Unknown Affiliation
Nzarubara, Bridget K.
Unknown Affiliation
Maiteki-Sebuguzi, Catherine
Unknown Affiliation
Staedke, Sarah G.
Unknown Affiliation
Seto, Edmund Yet Wah
Unknown Affiliation
Kamya, Moses Robert K.
Unknown Affiliation
Rosenthal, Philip Jon
Unknown Affiliation
Dorsey, Grant M.
Unknown Affiliation
Statistics
Citations: 154
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1086/589778
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda
Participants Gender
Female