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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Estrogen exposure and bladder cancer risk in Egyptian women
Maturitas, Volume 67, No. 4, Year 2010
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Description
Objective: To examine associations between reproductive history and urinary bladder cancer in Egyptian women. Methods: We used questionnaire data from an ongoing, multicenter case-control study in Egypt. Controls were matched on age and residence area. This analysis focused on female cases with confirmed urothelial (UC) and squamous cell (SCC) carcinoma of the bladder. Results: We recruited 779 women (540 controls, 239 cases; >98.0% nonsmokers). Younger age at menopause (<45 y) and older age at first pregnancy (>18 y) were factors significantly associated with increased risk of bladder cancer, even after adjusting for schistosomiasis history and other covariates in the multivariable logistic model; adjusted odds ratio and 95% confidence intervals were 1.98 (1.41, 2.77) and 6.26 (3.46, 11.34), respectively. On the other hand, multiple pregnancies or use of oral contraceptives were associated with decreased odds of having bladder cancer. Similar associations were observed with UC and SCC when analyzed separately; however, the magnitude of association with SCC was lower than with UC. Conclusion: Our data suggest that early estrogen exposure, or the relative lack of it, plays a role in urinary bladder carcinoma development among Egyptian women. © 2010 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Wolpert, Beverly J.
United States, Baltimore
University of Maryland School of Medicine
Amr, Sania
United States, Baltimore
University of Maryland School of Medicine
Ezzat, Sameera
Egypt, Shibin el Kom
Menoufia University
Saleh, Doa'a A.
Egypt, Giza
Cairo University
Gouda, Iman A.
Egypt, Giza
National Cancer Institute
Loay, Iman
Egypt, Giza
National Cancer Institute
Hifnawy, Tamer Mohamed Said
Egypt, Beni Suef
Beni-suef University
NNH Mikhail, Nabiel N.H.
Egypt, Asyut
Assiut University
Abdel-Hamid, Mohamed A.
Egypt, Minya
Minia University
Zhan, Min
United States, Baltimore
University of Maryland School of Medicine
Zheng, Yunling
United States, Washington, D.c.
Georgetown Lombardi Comprehensive Cancer Center
Squibb, Katherine
United States, Baltimore
University of Maryland School of Medicine
Abdel-Aziz, Mohamed Atef
Egypt, Asyut
Assiut University
Zaghloul, Mohamed S.
Egypt, Giza
National Cancer Institute
Khaled, Hussein Mostafa
Egypt, Giza
National Cancer Institute
Loffredo, Christopher A.
United States, Washington, D.c.
Georgetown Lombardi Comprehensive Cancer Center
Statistics
Citations: 42
Authors: 16
Affiliations: 8
Identifiers
Doi:
10.1016/j.maturitas.2010.07.014
ISSN:
03785122
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Locations
Egypt
Participants Gender
Female