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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rhinofacial conidiobolomycosis associated with cervical, thoracic and brachial localizations: One clinical case in Nigeria
Journal de Mycologie Medicale, Volume 24, No. 1, Year 2014
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Description
We report here the clinical case of a Nigerian adult patient who received medical care during October 2010, at the Center for Diagnosis and Treatment of Buruli ulcer in Pobè (Benin). He presented a massive facial tumor associated with several subcutaneous (cervical, thoracic and upper limbs) nodules, evolving since several years. Tissue samples collected at Pobè medical center were addressed to the mycology and histology laboratories of Angers University Hospital (France), according to the medical exchange agreement between the two institutions about the diagnosis and treatment of Buruli ulcer disease. Histological examination showed a Splendore-Hoeppli phenomenon, consisting of a granulomatous reaction made of eosinophilic polynuclear cells surrounding rare, large and irregular, non-septate hyphae. A filamentous fungus was isolated by cultivation of the clinical samples, which was identified as Conidiobolus coronatus. The patient was treated orally with daily doses of ketoconazole (400. mg per day). After 4. months of treatment, a marked regression of the facial lesion was obtained. A first constructive facial surgery was achieved, but the patient did not attend the second step. This case report allows us to remind the mycological diagnosis of this exotic mycosis, but also to emphasize the main difficulties encountered in medical management in the developing countries. © 2013 Elsevier Masson SAS.
Authors & Co-Authors
Twizeyimana, E.
France, Angers
Chu Angers
Chauty, Annick
Benin
Centre de Diagnostic et de Traitement de L'ulcère de Buruli
Pihet, M.
France, Angers
Chu Angers
Ardant, Marie Françoise
Benin
Centre de Diagnostic et de Traitement de L'ulcère de Buruli
Adéyé, Ambroise
Benin
Centre de Diagnostic et de Traitement de L'ulcère de Buruli
Zidane, M.
France, Angers
Chu Angers
de Gentile, Ludovic
France, Angers
Chu Angers
Saint-André, Jean Paul
France, Angers
Chu Angers
Chabasse, D.
France, Angers
Chu Angers
Statistics
Citations: 9
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/j.mycmed.2013.12.001
ISSN:
11565233
e-ISSN:
17730449
Research Areas
Cancer
Health System And Policy
Study Locations
Benin
Nigeria