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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Molecular epidemiology of human astrovirus and adenovirus serotypes 40/41 strains related to acute diarrhea in Tunisian children
Journal of Medical Virology, Volume 81, No. 11, Year 2009
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Description
Human astrovirus (AstV) and adenovirus types 40 and 41 (AdV 40/41) are responsible for epidemic and endemic acute gastroenteritis in children and adults. The present study was designed to evaluate the prevalence and genetic diversity of enteric viruses in children in Tunisia. A total of 788 fecal samples were collected during a 4-year period in the region of Monastir, from children under 12 years old, hospitalized or presenting in dispensaries with symptoms of acute gastroenteritis. AstV and AdV40/41 were detected by immunoenzymatic methods and confirmed by PCR/RT-PCR and sequence analysis. Phylogenetic analyseswereperformedfor nucleotide homology with reference strains. AstV and AdV40/41 were characterized as a causative agent in 28 (3.6%) and 18 (2.3%) of the fecal samples, respectively. Phylogenetic analysis showed that the AstVs belonged to the serotypes 3 (n = 4; 14.3%) and 1 (n = 24; 85.7%), and the enteric AdVs to the serotypes 40 (n = 1; 5.6%) and 41 (n = 17; 94.4%). This is the first report that describes the molecular epidemiology of AstV and AdV40/41 in Tunisian children. Their respective detection rate was very low, far below that of rotavirus and norovirus. The genetic diversity among these two viruses is relatively limited and varies depending on the area. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Sdiri-Loulizi, Khira
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Gharbi-Khélifi, Hakima
Tunisia, Monastir
Faculté de Pharmacie de Monastir
de Rougemont, Alexis
France, Dijon
Centre Hospitalier Universitaire Dijon Bourgogne
Hassine-Zaafrane, Mouna
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Chouchane, Slaheddine
Tunisia, Monastir
Chu Fattouma-bourguiba
Sakly, Nabil
Tunisia, Monastir
Chu Fattouma-bourguiba
Pothier, Pierre
France, Dijon
Centre Hospitalier Universitaire Dijon Bourgogne
Gueddiche, Mohamed Néji
Tunisia, Monastir
Chu Fattouma-bourguiba
Aouni, Mahjoub
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Ambert-Balay, Katia
France, Dijon
Centre Hospitalier Universitaire Dijon Bourgogne
Statistics
Citations: 47
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.21586
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Tunisia