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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Genetic diversity in exon 2 of the major histocompatibility complex class II DQB1 locus in nigerian goats
Biochemical Genetics, Volume 51, No. 11-12, Year 2013
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Description
The DQB1 locus is located in the major histocompatibility complex (MHC) class II region and involved in immune response. We identified 20 polymorphic sites in a 228 bp fragment of exon 2, one of the most critical regions of the MHC DQB1 gene, in 60 Nigerian goats. Four sites are located in the peptide binding region, and 10 amino acid substitutions are peculiar to Nigerian goats, compared with published sequences. A significantly higher ratio of nonsynonymous/synonymous substitutions (d N/d S) suggests that allelic sequence evolution is driven by balancing selection (P < 0.01). In silico functional analysis using PANTHER predicted that substitution P56R, with a subPSEC score of-4.00629 (Pdeleterious = 0.73229), is harmful to protein function. The phylogenetic tree from consensus sequences placed the two northern breeds closer to each other than either was to the southern goats. This first report of sequence diversity at the DQB1 locus for any African goat breed may be useful in the search for disease-resistant genotypes. © 2013 Springer Science+Business Media New York.
Authors & Co-Authors
Yakubu, Abdulmojeed
United States, Ithaca
Cornell University
Nigeria, Keffi
Nasarawa State University
Nigeria, Ibadan
University of Ibadan
Salako, Adebowale Emmanuel
Nigeria, Ibadan
University of Ibadan
De Donato-Capote, Marcos
United States, Ithaca
Cornell University
Venezuela, Cumana
Universidad de Oriente - Venezuela
Takeet, Michael Irewole
United States, Ithaca
Cornell University
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Peters, Sunday Olusola
United States, Ithaca
Cornell University
United States, Mount Berry
Berry College
Adefenwa, Mufliat A.
Nigeria, Lagos
University of Lagos
Okpeku, M.
Nigeria, Amassoma
Niger Delta University
Wheto, Mathew Y.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Agaviezor, Brilliant Ogagaoghene
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Nigeria, Port Harcourt
University of Port Harcourt
Sanni, Timothy M.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Ajayi, Oyeyemi Olugbenga
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Onasanya, Gbolabo Olaitan
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Ekundayo, Oludotun J.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Ilori, Babatunde M.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Amusan, Samuel A.
Nigeria, Abeokuta
Federal University of Agriculture, Abeokuta
Imumorin, Ikhide G.
United States, Ithaca
Cornell University
Statistics
Citations: 16
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1007/s10528-013-9620-y
ISSN:
00062928
e-ISSN:
15734927
Research Areas
Genetics And Genomics