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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chlamydia trachomatis infection as a risk factor for infertility among women in Ghana, West Africa
American Journal of Tropical Medicine and Hygiene, Volume 78, No. 2, Year 2008
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Description
In developing countries, data about the prevalence of genital Chlamydia trachomatis infections and their sequelae, especially tubal infertility, is scarce. A prospective case-control study was performed enrolling 439 Ghanaian women. The case group included 191 patients with primary or secondary infertility. The control group consisted of 248 healthy pregnant women. First-void urine samples were investigated by PCR, and serum specimens were tested for C. trachomatis-specific IgG and IgA antibodies. Demographic and behavioral information were gathered for statistical analysis. The PCR prevalence of C. trachomatis was relatively low and did not differ significantly among both groups (2.4 versus 1.6%). In contrast, significantly higher prevalences of specific IgG (39% versus 19%) and IgA (14% versus 3%) antibodies were found among infertile women. The adjusted odds ratios were 2.1 and 2.8, respectively. Our data suggest that previous C. trachomatis infections may contribute to infertility in Ghanaian women. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Siemer, Jorn
Germany, Erlangen
Universitätsklinikum Erlangen
Theile, Oliver
Germany, Ulm
Universitätsklinikum Ulm
Larbi, Yaw
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Fasching, Peter Andreas
Germany, Erlangen
Universitätsklinikum Erlangen
Danso, Kwabena Asimeng
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Kreienberg, Rolf
Germany, Ulm
Universitätsklinikum Ulm
Essig, Andreas
Germany, Ulm
Universitätsklinikum Ulm
Statistics
Citations: 72
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2008.78.323
ISSN:
00029637
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Multi-countries
Ghana
Participants Gender
Female