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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Ethno-veterinary medicine: Screening of Nigerian medicinal plants for trypanocidal properties
Journal of Ethnopharmacology, Volume 77, No. 1, Year 2001
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Description
Trypanosoma congolense and T. brucei bloodstream form parasites were propagated axenically in suitable standard media at 34°C. The effects of 33 plant extracts, fractions and pure compounds were evaluated on two clones of T. brucei and drug-sensitive and multi-drug-resistant clones of T. congolense. The cytotoxic activity of the trypanocidal extracts was also evaluated on calf aorta endothelial cells in vitro. Of the extracts tested, 22% killed T. congolense IL 1180 at a concentration of 100 μg/ml while 18% killed 90-100% of T. brucei ILTat 1.4 at the same concentration. However, 6% of the active extracts killed 93% of a dyskinetoplastid form of T. brucei IL Tat 1.1, indicating that the intact kinetoplast is a target of some of the compounds tested. Of the 12 extracts that displayed activity against drug sensitive trypanosomes, 66.7% had trypanocidal activity on a multi-drug-resistant clone, T. congolense IL 3338. The extracts of Eugenia uniflora, Acacia artaxacantha, Terminalia ivorensis, T. superba and Alchornea cordifolia had median lethal concentrations of between 13 and 69 μg/ml on both the drug-sensitive, IL 1180 and multi-drug-resistant clone, IL 3338. The median lethal doses of the active plant extracts on the calf aorta endothelial cells varied between 112 and 13 750 μg/ml while the calculated selective indices ranged between 0.71 and 246.8 indicating bright prospects for the development of some of these extracts as potential trypanocidal agents. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Authors & Co-Authors
Adewunmi, Clement Oladapo
Nigeria, Ife
Obafemi Awolowo University
Agbedahunsi, Joseph Morohunfolu
Nigeria, Ife
Obafemi Awolowo University
Adebajo, A. C.
Nigeria, Ife
Obafemi Awolowo University
Aladesanmi, Adetunji Joseph
Nigeria, Ife
Obafemi Awolowo University
Murphy, Noel B.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Wando, John R.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 107
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/S0378-8741(01)00247-1
ISSN:
03788741
Research Areas
Health System And Policy