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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Eosinophilia and eosinophil helminthotoxicity in patients treated for Schistosoma mansoni infections
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 85, No. 4, Year 1991
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Description
The changes in eosinophil levels and in eosinophilmediated antibody-dependent schistosomular cytotoxicity, following treatment for Schistosoma mansoni infections, have been investigated in 2 similar groups of patients aged 15-50 years. Patients in group 1 were treated with either hycanthone or oxamniquine, and those in group 2 with hycanthone or praziquantel. Eosinophil levels were significantly increased in both groups. In group 1 peripheral blood eosinophil counts rose from a mean of 175/μl before treatment to 745/μl 3 weeks after treatment, and in group 2 from 181/μl to 1066/μl. The increase in eosinophil levels was positively correlated with a rise in circulating anti-adult worm antibodies (r = -0·587, P < 0·05), whereas a negative correlation was recorded with anti-egg antibodies (r = -0·727). Despite some enhanced eosinophil helminthotoxicity following treatment in some of the individuals in group 1 ( 7 15), the change overall was not significant. In group 2, in which a different standard anti-schistosomular antibody was used, the eosinophil killing capacity recorded at 3 weeks was lower than that before commencement of treatment (t = 2·89, P < 0·01). The eosinophil stimulating activity, detected in cultured mononuclear cell supernatants (MCS) from individual patients, correlated with eosinophil levels (r = 0·582, P < 0·02) but there was no association with eosinophil killing. MCS activity did not appear to be boosted by treatment. These studies showed that peripheral blood eosinophil counts were increased following treatment, but their ability to kill schistosome larvae is variable and may depend on the immune serum used as the source of anti-schistosomular antibody. © 1991.
Authors & Co-Authors
Kimani, Gachuhi G.
Kenya, Nairobi
Biomedical Sciences Centre
Change, C. N.
Kenya, Nairobi
University of Nairobi
Butterworth, Anthony E.
United Kingdom, Cambridge
University of Cambridge
Kamau, Timothy
Kenya, Nairobi
Biomedical Sciences Centre
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Gachihi, George S.
Kenya, Nairobi
Clinical Research Centre
Mungai, Benjamin N.
Kenya, Nairobi
Biomedical Sciences Centre
Mugambi, Mutama
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 18
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(91)90231-M
ISSN:
00359203