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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti
Malaria Journal, Volume 12, No. 1, Article 201, Year 2013
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Description
Background: Case management of imported malaria within the context of malaria pre-elimination is increasingly considered to be relevant because of the risk of resurgence. The assessment of malaria importation would provide key data i) to select countries with propitious conditions for pre-elimination phase and ii) to predict its feasibility. Recently, a sero-prevalence study in Djibouti indicated low malaria prevalence, which is propitious for the implementation of pre-elimination, but data on the extent of malaria importation remain unknown. Methods. Djiboutian plasmodial populations were analysed over an eleven-year period (1998, 1999, 2002 and 2009). The risk of malaria importation was indirectly assessed by using plasmodial population parameters. Based on 5 microsatellite markers, expected heterozygosity (H.e.), multiplicity of infection, pairwise Fst index, multiple correspondence analysis and individual genetic relationship were determined. The prevalence of single nucleotide polymorphisms associated with pyrimethamine resistance was also determined. Results: Data indicated a significant decline in genetic diversity (0.51, 0.59, 0.51 and 0 in 1998, 1999, 2002 and 2009, respectively) over the study period, which is inconsistent with the level of malaria importation described in a previous study. This suggested that Djiboutian malaria situation may have benefited from the decline of malaria prevalence that occurred in neighbouring countries, in particular in Ethiopia. The high Fst indices derived from plasmodial populations from one study period to another (0.12 between 1999 and 2002, and 0.43 between 2002 and 2009) suggested a random sampling of parasites, probably imported from neighbouring countries, leading to oligo-clonal expansion of few different strains during each transmission season. Nevertheless, similar genotypes observed during the study period suggested recurrent migrations and imported malaria. Conclusion: In the present study, the extent of genetic diversity was used to assess the risk of malaria importation in the low malaria transmission setting of Djibouti. The molecular approach highlights i) the evolution of Djiboutian plasmodial population profiles that are consistent and compatible with Djiboutian pre-elimination goals and ii) the necessity to implement the monitoring of plasmodial populations and interventions at the regional scale in the Horn of Africa to ensure higher efficiency of malaria control and elimination. © 2013 Khaireh et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S1.tiff
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S2.tiff
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S3.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S4.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S5.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S6.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3685531/bin/1475-2875-12-201-S7.doc
Authors & Co-Authors
Khaireh, Bouh Abdi
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Djibouti
Dss/rqg
Djibouti, Djibouti
Centre D'etudes et de Recherche de Djibouti
Assefa, Ashenafi
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Guessod, Hawa Hassan
Djibouti
Ministère de la Santé
Basco, Leonardo K.
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Khaireh, Mohamed Abdi
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Pascual, Aurélie M.
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Briolant, Sébastien
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Bouh, Samatar Mohamed
Djibouti
Institut National de Santé Publique
Farah, Ismaïl Hassan
Djibouti
Dss/rqg
Ali, Habib Moussa
Djibouti
Dss/rqg
Abdi, Abdoul Ilah Ahmed
Djibouti
Dss/rqg
Aden, Mouna Osman
Djibouti
Ministère de la Santé
Abdillahi, Zamzam
Djibouti
Ministère de la Santé
Ayeh, Souleiman Nour
Djibouti, Djibouti
Hôpital Général Peltier
Darar, Houssein Youssouf
Djibouti
Institut National de Santé Publique
Djibouti, Djibouti
Hôpital Général Peltier
Koeck, Jean Louis
Djibouti
Centre Hospitalier Des Armées Bouffard
Rogier, Christophe
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Pradines, Bruno
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Bogreau, Hervé
France, Marseille
Unité de Parasitologie
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Statistics
Citations: 29
Authors: 19
Affiliations: 10
Identifiers
Doi:
10.1186/1475-2875-12-201
e-ISSN:
14752875
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Djibouti
Ethiopia