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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe
Clinical Infectious Diseases, Volume 62, No. 5, Year 2016
Notification
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Description
Background. Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. Methods. Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0. Results. The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%-9.5%) in 2008-2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. Conclusions. Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected. © The Author 2015.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4741360/bin/supp_62_5_655__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4741360/bin/supp_civ963_civ963supp.docx
Authors & Co-Authors
Hofstra, Laura Marije
Luxembourg, Strassen
Luxembourg Institute of Health
Netherlands, Utrecht
University Medical Center Utrecht
Sauvageot, Nicolas
Luxembourg, Strassen
Luxembourg Institute of Health
Albert, Jan
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Alexiev, Ivailo
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
García, Federico Alcacer
Spain, Granada
Complejo Hospitalario Universitario de Granada
Struck, Daniel
Luxembourg, Strassen
Luxembourg Institute of Health
Van De Vijver, D. A.M.C.
Netherlands, Rotterdam
Erasmus Mc
Åsjö, Birgitta
Norway, Bergen
Universitetet I Bergen
Beshkov, Danail
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Descamps, Diáne
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Hamouda, Osamah
Germany, Berlin
Robert Koch Institute
Horban, Andrzéj
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Kostrikis, Leontios G.
Cyprus, Nicosia
University of Cyprus
Liitsola, Kirsi
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Linka, Marek
Czech Republic, Prague
National Institute of Public Health Prague
Mor, Orna
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Nielsen, Claus M.
Denmark, Copenhagen
Statens Serum Institut
Oţelea, Dan
Romania, Bucharest
National Institute for Infectious Diseases Prof. Dr. Matei Bals
Paraskevis, D. N.
Greece, Athens
National and Kapodistrian University of Athens
Paredes, Roger
Unknown Affiliation
Poljak, Mario
Slovenia, Ljubljana
Univerza V Ljubljani
Puchhammer-Stöckl, Elisabeth
Austria, Vienna
Medizinische Universität Wien
Sönnerborg, Anders B.
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Stanojevic, Maja
Serbia, Belgrade
University of Belgrade
van Laethem, Kristel V.
Belgium, Leuven
Ku Leuven
Zazzi, Maurizio
Italy, Siena
Università Degli Studi Di Siena
Zidovec Lepej, Snjezana
Croatia, Zagreb
University Hospital for Infectious Diseases dr Fran Mihaljevic
Boucher, Charles A.B.
Netherlands, Rotterdam
Erasmus Mc
Schmit, Jean Claude
Luxembourg, Strassen
Luxembourg Institute of Health
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Sarcletti, Mario
Unknown Affiliation
Vandamme, Anne Mieke
Unknown Affiliation
Vercauteren, Jurgen
Unknown Affiliation
de Roo, Ann
Unknown Affiliation
de Wit, Stéphane A.
Unknown Affiliation
Fransen, Katrien
Unknown Affiliation
Goffard, J. C.
Unknown Affiliation
Goubau, Patrick
Unknown Affiliation
Yombi, Jean Cyr
Unknown Affiliation
Lacor, Patrick
Unknown Affiliation
Liesnard, Corinne A.
Unknown Affiliation
Moutschen, Michel
Unknown Affiliation
Piérard, Dénis
Unknown Affiliation
Vaira, Dolorès
Unknown Affiliation
Vandekerckhove, Linos P.R.
Unknown Affiliation
van Ranst, Marc A.
Unknown Affiliation
Vandercam, Bernard C.
Unknown Affiliation
Vekemans, Marc
Unknown Affiliation
Verhofstede, Chris
Unknown Affiliation
Clumeck, Nathan N.
Unknown Affiliation
Begovac, J.
Unknown Affiliation
Malý, Marek
Unknown Affiliation
Jörgensen, Louise Bruun
Unknown Affiliation
Gerstoft, Jan
Unknown Affiliation
Pedersen, Court K.
Unknown Affiliation
Laursen, Alex Lund
Unknown Affiliation
Kvinesdal, Birgit Bak
Unknown Affiliation
Ristola, M.
Unknown Affiliation
Assoumou, Lambert K.
Unknown Affiliation
Grudé, Maxime
Unknown Affiliation
Flandre, Philippe
Unknown Affiliation
Storto, Alexandre
Unknown Affiliation
Kücherer, Claudia
Unknown Affiliation
Berg, Thomas
Unknown Affiliation
Braun, Patrick
Unknown Affiliation
Poggensee, Gabriele
Unknown Affiliation
Däumer, Martin P.
Unknown Affiliation
Eberle, Josef A.
Unknown Affiliation
Kaiser, Rolf
Unknown Affiliation
Knechten, Heribert
Unknown Affiliation
Korn, Klaus
Unknown Affiliation
Schmidt, Barbara
Unknown Affiliation
Gunsenheimer-Bartmeyer, Barbara
Unknown Affiliation
Harrer, Thomas
Unknown Affiliation
Hatzakis, Angelos E.
Unknown Affiliation
Lazanas, Marios C.
Unknown Affiliation
Paparizos, Vassilios A.
Unknown Affiliation
Antoniadou, Anastasia C.
Unknown Affiliation
Papadopoulos, Antonios I.
Unknown Affiliation
Poulakou, Garyphallia G.
Unknown Affiliation
Protopapas, Konstantinos
Unknown Affiliation
Psichogiou, Mina A.
Unknown Affiliation
Daikos, Georgios L.
Unknown Affiliation
Skoutelis, Athanasios Th
Unknown Affiliation
Papastamopoulos, V.
Unknown Affiliation
Maltezos, Efstratios
Unknown Affiliation
de Gascun, Cillian F.
Unknown Affiliation
Bergin, Colm J.
Unknown Affiliation
Lambert, John Shearer
Unknown Affiliation
Hall, William W.
Unknown Affiliation
Chemtob, Daniel
Unknown Affiliation
Grossman, Zehava
Unknown Affiliation
de Luca, Andrea
Unknown Affiliation
Balotta, Claudia
Unknown Affiliation
Mussini, Cristina
Unknown Affiliation
Capetti, Amedeo Ferdinando
Unknown Affiliation
Ciccozzi, M.
Unknown Affiliation
Rezza, Giovanni
Unknown Affiliation
Hemmer, Robert J.P.
Unknown Affiliation
Arendt, Vic
Unknown Affiliation
Staub, Thérèse
Unknown Affiliation
Brinkman, Kees
Unknown Affiliation
Connell, Bridgette Janine
Unknown Affiliation
van der Ende, Marchina Elisabeth
Unknown Affiliation
Hoepelman, Ilja M.
Unknown Affiliation
Richter, Clemens
Unknown Affiliation
Schuurman, Rob J.
Unknown Affiliation
Kran, Anne Marte Bakken
Unknown Affiliation
Ormaasen, Vidar
Unknown Affiliation
Camacho, Ricardo Jorge
Unknown Affiliation
Duque, Vítor
Unknown Affiliation
Paraschiv, Simona
Unknown Affiliation
Cernat, Roxana Carmen
Unknown Affiliation
Jevtović, Djordje Ljubomir
Unknown Affiliation
Bukovinová, Pavlina
Unknown Affiliation
Truska, Peter
Unknown Affiliation
Lunar, Maja M.
Unknown Affiliation
Tomažič, Janez
Unknown Affiliation
Monge, Susana
Unknown Affiliation
Moreno, Santiago C.
Unknown Affiliation
del Amo, Julia
Unknown Affiliation
de-Mendoza, Carmen
Unknown Affiliation
Delgado, Rafael Díez
Unknown Affiliation
Gutieŕrez, Félix
Unknown Affiliation
Berenguer, Juan J.
Unknown Affiliation
Stella, Natalia C.
Unknown Affiliation
de Los Santos-Gil, Ignacio
Unknown Affiliation
Dalmau, David
Unknown Affiliation
Aguilera, Antonio
Unknown Affiliation
Domingo, Pere
Unknown Affiliation
Miralles, Celia
Unknown Affiliation
Ruíz, Lídia
Unknown Affiliation
Clotet, Bonaventura
Unknown Affiliation
Karlsson, Anders Cecilia
Unknown Affiliation
Thalme, Anders
Unknown Affiliation
Navèr, Lars
Unknown Affiliation
Bratt, Göran A.
Unknown Affiliation
Blaxhult, Anders
Unknown Affiliation
Gisslèn, Magnus
Unknown Affiliation
Björkman, Per
Unknown Affiliation
Mellgren, Åsa
Unknown Affiliation
Azimi, Farshad C.
Unknown Affiliation
Johansson, Bo C.
Unknown Affiliation
Ekvall, Håkan
Unknown Affiliation
Statistics
Citations: 132
Authors: 144
Affiliations: 26
Identifiers
Doi:
10.1093/cid/civ963
ISSN:
10584838
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study