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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of rotavirus vaccines in Asia-Are there lessons to be learnt?
Vaccine, Volume 27, No. SUPPL. 5, Year 2009
Notification
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Description
Rotavirus mortality is highest in the Asia-Pacific region and rotavirus vaccines could have enormous impact here. Yet, live-attenuated orally administered rotavirus vaccines have been evaluated in a small number of immunogenicity studies in some Asian countries, where the immune responses have been documented to be moderate in low-income countries with high diarrhoeal disease burden and mortality, and high in middle-/high-income countries with little reported rotavirus deaths. This review of these rotavirus clinical trials examines the results observed and attempts to draw lessons to inform decision-making, aid design of additional clinical trials and guide vaccine development by local manufacturers. © 2009 Elsevier Ltd.
Authors & Co-Authors
Steele, Andrew Duncan
United States, Seattle
Path Seattle
Switzerland, Geneva
Organisation Mondiale de la Santé
Parashar, Umesh D.
United States, Atlanta
Centers for Disease Control and Prevention
Zaman, Khalequzzaman S.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Neuzil, Kathleen Maletic
United States, Seattle
Path Seattle
United States, Seattle
University of Washington
Nelson, Edmund Anthony Severn
Hong Kong, Hong Kong
Chinese University of Hong Kong
Statistics
Citations: 6
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1016/j.vaccine.2009.09.039
ISSN:
0264410X