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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea
Journal of Medical Virology, Volume 78, No. 11, Year 2006
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Description
The incidence of calicivirus infection in Ghana and many other African countries is not known. Thirteen (15.9%) of the 82 diarrhoeic stool samples tested for caliciviruses were positive for noroviruses (NoVs). NoVs were present in all age groups and were detected only during the diarrhoea peak that coincided with the peak rotavirus season. Ten (76.9%) of the NoV detected were genogroup II (GII) NoVs and the remaining three (23.1%) genogroup I (GI) NoVs. The predominant GII detected was GII-4 (60%, 6/10). Three of the GII NoVs were determined to be recombinants of GII-8/GII-14 as deduced from the sequencing of the region spanning the Orf1/2 junction. The GII genotypes formed four clusters with published GII sequences. The data shown enhances understanding of NoV diversity in Ghanaian children and demonstrate the global spread of distinct common genotypes to African countries. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Armah, George Enyimah
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Gallimore, Chris I.
United Kingdom, London
Enteric Virus Unit
Binka, Fred Newton
Ghana
Centre
Asmah, Richard Harry
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Green, Jonathan
United Kingdom, London
Enteric Virus Unit
United Kingdom, London
Public Health England
Ugoji, Ucheoma
United Kingdom, London
Enteric Virus Unit
Anto, Francis R.
Ghana
Centre
Brown, David W.G.
United Kingdom, London
Public Health England
Gray, Jim J.
United Kingdom, London
Enteric Virus Unit
Statistics
Citations: 41
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1002/jmv.20722
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Ghana