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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Investigating the pathogenesis of severe malaria: A multidisciplinary and cross-geographical approach
American Journal of Tropical Medicine and Hygiene, Volume 93, Year 2015
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Description
More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of severe malaria is still not well understood. The majority of malaria cases are caused by Plasmodium falciparum and Plasmodium vivax, which differ in virulence, red blood cell tropism, cytoadhesion of infected erythrocytes, and dormant liver hypnozoite stages. Cerebral malaria coma is one of the most severe manifestations of P. falciparum infection. Insights into its complex pathophysiology are emerging through a combination of autopsy, neuroimaging, parasite binding, and endothelial characterizations. Nevertheless, important questions remain regarding why some patients develop life-threatening conditions while the majority of P. falciparum-infected individuals do not, and why clinical presentations differ between children and adults. For P. vivax, there is renewed recognition of severe malaria, but an understanding of the factors influencing disease severity is limited and remains an important research topic. Shedding light on the underlying disease mechanisms will be necessary to implement effective diagnostic tools for identifying and classifying severe malaria syndromes and developing new therapeutic approaches for severe disease. This review highlights progress and outstanding questions in severe malaria pathophysiology and summarizes key areas of pathogenesis research within the International Centers of Excellence for Malaria Research program. © 2015 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Wassmer, Samuel Crocodile
United States, East Lansing
Michigan State University
Taylor, Terrie Ellen
United States, East Lansing
Michigan State University
Rathod, Pradipsinh K.
United States, East Lansing
Michigan State University
Mishra, Saroj Kanti
United States, East Lansing
Michigan State University
Mohanty, Sanjib S.
United States, East Lansing
Michigan State University
Arev́alo-Herrera, Myriam
United States, East Lansing
Michigan State University
Duraisingh, Manoj Theodore
United States, East Lansing
Michigan State University
Smith, Joseph D.
United States, Seattle
Seattle Biomedical Research Institute
Statistics
Citations: 146
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.4269/ajtmh.14-0841
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health