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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Primary hepatic sarcomas in children - A single-center experience over 19 years
Journal of Pediatric Surgery, Volume 45, No. 11, Year 2010
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Description
Background/ Purpose: Primary hepatic sarcomas are rare and account for about 13% of primary hepatic neoplasms. There are few reported series of pediatric hepatic sarcomas, and the aim was to review our experience. Methods: A retrospective analysis of cases managed from 1988 to 2007 by the pediatric liver unit in Birmingham, UK, was conducted. Results: Nineteen children were identified. These presented with sudden abdominal pain (n = 6), obstructive jaundice (n = 3), incidental mass (n = 3), and chronic pain/distension (n = 3). Vascular involvement was identified in 3, and 6 had pulmonary metastases. Three patients had primary resection, and 3 only a biopsy. Thirteen had a biopsy followed by chemotherapy and resection. Surgery included extended hepatectomy (n = 11), hepatectomy (n = 3), and nonanatomical resections (n = 2). There was 1 major intraoperative complication. Median inpatient stay was 7 days. One biliary leak developed 4 weeks postoperatively. Five of the 16 patients who underwent resection of the primary tumor died. Eleven were alive at a median follow-up of 3 years. Conclusion: This is a challenging group of patients. Local control remains pivotal to successful treatment. Good results can be achieved in a specialist center with multidisciplinary approach. © 2010 Elsevier Inc. All rights reserved.
Authors & Co-Authors
McKiernan, Patrick James
United Kingdom, Birmingham
Birmingham Children's Hospital
Kelly, Deirdre Anne K.
United Kingdom, Birmingham
Birmingham Children's Hospital
Brown, Rachel Mary
United Kingdom, Birmingham
Birmingham Children's Hospital
Lloyd, Carla
United Kingdom, Birmingham
Birmingham Children's Hospital
Buckels, John A.C.
United Kingdom, Birmingham
Birmingham Children's Hospital
Millar, Allistair John Ward
United Kingdom, Birmingham
Birmingham Children's Hospital
De Ville Goyet, Jean
United Kingdom, Birmingham
Birmingham Children's Hospital
Mirza, Darius Feroze
United Kingdom, Birmingham
Birmingham Children's Hospital
Sharif, Khalid
United Kingdom, Birmingham
Birmingham Children's Hospital
Statistics
Citations: 12
Authors: 9
Affiliations: 1
Identifiers
Doi:
10.1016/j.jpedsurg.2010.07.016
ISSN:
00223468
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study