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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Distinct association of factor V-Leiden and prothrombin G20210A mutations with deep venous thrombosis in Tunisia and Lebanon
American Journal of Hematology, Volume 81, No. 8, Year 2006
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Description
Factor V G1691A (FV-Leiden) and prothrombin (PRT) G20210A single nucleotide polymorphisms (SNPs) were associated with venous thrombosis among Caucasians. We assessed the contribution of both SNPs to the genetic susceptibility of deep venous thrombosis (DVT) among Lebanese and Tunisian patients. Subjects comprised 198 DVT patients and 540 healthy controls from Lebanon and 126 Tunisian DVT patients and 197 control subjects; FV-Leiden (MnA) and PRT G20210A (HindIII) genotyping was done by PCR-RFLP. While the prevalence of FV-Leiden mutant A allele and the G/A and A/A genotypes were significantly higher among DVT patients from Lebanon and Tunisia, the association of PRT G20210A with DVT was pronounced among Lebanese but not Tunisian patients. The prevalence of PRT G20210A mutant A allele (P < 0.001 vs. P = 181) and G/A genotype (P < 0.001 vs. P = 0.994) was significantly higher among Lebanese but not Tunisians, respectively. While FV-Leiden was a common genetic risk factor for DVT in both communities, the contribution of PRT G20210A to the genetic susceptibility of DVT differed among Lebanese and Tunisians, which underscores the need to determine prothrombolic gene polymorphisms associated with DVT among Arab and Mediterranean basin communities. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Bouaziz-Borgi, Lobna
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Lebanon, Beirut
Haigazian University
Mtiraoui, Nabil
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Nsiri, Brahim
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Militaire de Tunis
Keleshian, Sose H.
Lebanon, Beirut
Haigazian University
Kreidy, Raghid
Lebanon, Beirut
St. Georges University Hospital
Hézard, Nathalie
France, Reims
Hopital Robert Debre Chu de Reims
Mahjoub, Touhami
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 27
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1002/ajh.20582
ISSN:
03618609
e-ISSN:
10968652
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Tunisia