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Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears

Antimicrobial Agents and Chemotherapy, Volume 51, No. 8, Year 2007

We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Diacon, Andreas Henri
1. South Africa, Bellville Dst/nrf Centre of Excellence for Biomedical tb Research
2. South Africa, Cape Town Stellenbosch University, Faculty of Medicine and Health Sciences
Patientia, R. F.
1. South Africa, Bellville Karl Bremer Hospital
Venter, Amour
1. South Africa, Bellville Dst/nrf Centre of Excellence for Biomedical tb Research
Van Helden, Paul D.
1. South Africa, Bellville Dst/nrf Centre of Excellence for Biomedical tb Research
Smith, Peter J.D.
1. South Africa, Cape Town University of Cape Town
McIlleron, Helen Margaret
1. South Africa, Cape Town University of Cape Town
Maritz, Johannes Stephanus
1. South Africa, Tygerberg South African Medical Research Council
Donald, Peter Roderick
1. South Africa, Cape Town Stellenbosch University, Faculty of Medicine and Health Sciences

AFRICAN RESEARCH NEXUS

Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears

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AFRICAN RESEARCH NEXUS

Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears

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African Research Nexus

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