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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evaluation of FDA licensed HIV assays using plasma from Cameroonian blood donors
Journal of Medical Virology, Volume 78, No. SUPPL. 1, Year 2006
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Description
Several diagnostic assays for the detection of HIV infection have been approved and licensed by the FDA for blood donor screening. However, the performance of these assays is unknown when testing genetically divergent blood specimens. To evaluate the performance of these assays with diverse HIV strains, we chose to study specimens collected from blood donors in Cameroon where genetic diversity and recombinant variants are prevalent. In this study, we tested 240 human plasma specimens collected from two blood centers in Cameroon. These samples were screened initially in Cameroon for antibody to HIV using a rapid assay. We also performed sequencing to determine subtype. Our evaluation has demonstrated that HIV infection in most HIV plasma samples could be detected by most of the US FDA licensed diagnostic assays. With the exception of a few specimens, HIV-1 p24 antigen was not detected in any of the samples. In addition, some nucleic acid tests (NAT) assays were not able to detect a few serologic reactive samples and all new variants including some CRF02_AG variants. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Lee, Sherwin F.
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Hu, Jinjie
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Tang, Shixing
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Wood, Owen
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Francis, Kori
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Machuca, Ana
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Ríos, Maria
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Daniel, Sylvester
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Vockley, Christopher
United States, Bethesda
Fda Center for Biologics Evaluation and Research
Awazi, Bih
Cameroon
Sanitation and Hygiene
Zekeng, Leópold
Cameroon
Sanitation and Hygiene
Hewlett, Indira K.
United States, Bethesda
Fda Center for Biologics Evaluation and Research
United States, Bethesda
Lab of Molecular Virology
Statistics
Citations: 12
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.20602
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Cameroon