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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Presence of drug resistance mutations among drug-naive patients in Morocco
AIDS Research and Human Retroviruses, Volume 27, No. 8, Year 2011
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Description
The aim of the present study was to determine viral subtypes and resistance mutations to antiretroviral treatment (ART) in HIV-1-infected treatment-naive patients from Rabat, Morocco during the period 2005-2009. The protease and reverse transcriptase (RT) genes were sequenced, the phylogenetic trees were inferred, and the resistance-associated mutations to NRTIs, NNRTIs, and PIs were recorded according to the international list of surveillance drug resistance mutations (SDRMs). The viral subtypes were subtype B (74%), CRF02-AG (15%), A1 (6%), C (2%), F1 (1%), CRF09 (1%), and CRF25-cpx (1%). The presence of DRMs was found in four (5.06%) of 91 patients; resistance mutations to NRTIs were M184V and T215I/S revertant mutations; resistance to NNRTIs was associated with K103N and resistance to PIs with V82A. These findings have relevant implications for the local molecular mapping of HIV-1 and future ART surveillance studies in the region. © Copyright 2011, Mary Ann Liebert, Inc.
Authors & Co-Authors
El Annaz, Hicham
Morocco, Agdal Rabat
Military Hospital Mohammed V
Recordon-Pinson, Patricia
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Baba, Nabil
Morocco, Agdal Rabat
Military Hospital Mohammed V
Sedrati, Omar L.
Morocco, Agdal Rabat
Military Hospital Mohammed V
Mrani, Saad
Morocco, Agdal Rabat
Military Hospital Mohammed V
Fleury, Hervè J.A.
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Statistics
Citations: 16
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1089/aid.2010.0284
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Infectious Diseases
Study Locations
Morocco