Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal
PLoS ONE, Volume 8, No. 4, Article e60780, Year 2013
Notification
URL copied to clipboard!
Description
Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign. © 2013 Daniels et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s001.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s002.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s003.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s004.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s005.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s006.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s007.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s008.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s009.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3617153/bin/pone.0060780.s010.xlsx
Authors & Co-Authors
Daniels, Rachel F.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Cambridge
Broad Institute
Chang, Hsiaohan
United States, Cambridge
Harvard University
Sène, Papa Diogoye
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Park, Danny C.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
Neafsey, Daniel E.
United States, Cambridge
Broad Institute
Schaffner, Stephen F.
United States, Cambridge
Broad Institute
Hamilton, Elizabeth J.
United States, Cambridge
Harvard University
Lukens, Amanda K.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Cambridge
Broad Institute
Van-Tyne, Daria
United States, Boston
Harvard T.h. Chan School of Public Health
Mboup, Souleymane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sabeti., Pardis C.
United States, Cambridge
Broad Institute
United States, Cambridge
Harvard University
United States, Cambridge
Harvard Faculty of Arts and Sciences
Ndiaye, Daouda F.
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Wirth, Dyann F.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Cambridge
Broad Institute
Hartl, Daniel L.
United States, Cambridge
Harvard University
Volkman, Sarah K.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Cambridge
Broad Institute
United States, Boston
Simmons University
Statistics
Citations: 90
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0060780
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Senegal