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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation
Parasitology International, Volume 62, No. 6, Year 2013
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Description
Granuloma formation around parasite eggs during schistosomal infection is considered to be controlled by Th2 cytokines. However, it is still controversial which cell populations are responsible for the host Th2 cytokine-dependent granuloma formation. Basophils have recently attracted attention because of their ability to produce large amounts of IL-4. Therefore, we investigated whether basophils play an essential role in the induction of granuloma formation induced by Schistosoma mansoni eggs. Together with our previous observation that basophil numbers increased markedly in the spleen at 7. weeks postinfection, immunohistochemical staining using anti-mMCP8 monoclonal antibody (mAb) showed basophil infiltration in the granulomatous lesions formed around parasite eggs. To examine the roles of basophils more directly, we treated mice with anti-CD200R3 mAb to deplete basophils. Depletion of basophils resulted in a reduction of basophil number with concomitant downregulation of egg granuloma formation at 7. weeks postinfection. Moreover, we observed a significant reduction in the size of egg granulomas formed in basophil-depleted mice in the pulmonary granuloma model. Taken together, these findings indicated that basophils are essential for S. mansoni egg-induced granuloma formation, and this may serve as a novel therapeutic target in ameliorating the pathology of schistosomiasis. © 2013 Elsevier Ireland Ltd.
Authors & Co-Authors
Anyan, William Kofi
Japan, Tokyo
Tokyo Medical and Dental University
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Seki, Takenori
Japan, Tokyo
Tokyo Medical and Dental University
Kumagai, Takashi
Japan, Tokyo
Tokyo Medical and Dental University
Obata-Ninomiya, Kazushige
Japan, Tokyo
Tokyo Medical and Dental University
Furushima-Shimogawara, Rieko
Japan, Tokyo
Tokyo Medical and Dental University
Kwansa-Bentum, Bethel
Japan, Tokyo
Tokyo Medical and Dental University
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ghana, Accra
University of Ghana
Akao, Nobuaki
Japan, Tokyo
Tokyo Medical and Dental University
Bosompem, Kwabena Mante
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Boakye, Daniel Adjei
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Wilson, Michael David
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Karasuyama, Hajime
Japan, Tokyo
Tokyo Medical and Dental University
Ohta, Nobuo
Japan, Tokyo
Tokyo Medical and Dental University
Statistics
Citations: 23
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/j.parint.2013.07.003
ISSN:
13835769
e-ISSN:
18730329
Research Areas
Infectious Diseases