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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
arts and humanities
Cognition and lobar morphology in full mutation boys with fragile X syndrome
Brain and Cognition, Volume 78, No. 1, Year 2012
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Description
The aims of the present study are twofold: (1) to examine cortical morphology (CM) associated with alterations in cognition in fragile X syndrome (FXS); (2) to characterize the CM profile of FXS versus FXS with an autism diagnosis (FXS. +. Aut) as a preliminary attempt to further elucidate the behavioral distinctions between the two sub-groups. We used anatomical magnetic resonance imaging surface-based morphometry in 21 male children (FXS N= 11 and age [2.27-13.3] matched controls [C] N= 10). We found (1) increased whole hemispheric and lobar cortical volume, cortical thickness and cortical complexity bilaterally, yet insignificant changes in hemispheric surface area and gyrification index in FXS compared to C; (2) linear regression analyses revealed significant negative correlations between CM and cognition; (3) significant CM differences between FXS and FXS. +. Aut associated with their distinctive behavioral phenotypes. These findings are critical in understanding the neuropathophysiology of one of the most common intellectual deficiency syndromes associated with altered cognition as they provide human in vivo information about genetic control of CM and cognition. © 2011 Elsevier Inc.
Authors & Co-Authors
Abdel-Meguid, N.
Egypt, Giza
National Research Centre
Fahim, Chérine
Switzerland, Lausanne
Université de Lausanne Unil
Canada, Montreal
Mcconnell Brain Imaging Centre
Sami, Rasha
Egypt, Giza
National Research Centre
Nashaat, Neveen Hassan
Egypt, Giza
National Research Centre
Yoon, Uicheul
Canada, Montreal
Mcconnell Brain Imaging Centre
South Korea, Gyeongsan
Catholic University of Daegu
Anwar, Mona
Egypt, Giza
National Research Centre
El-Dessouky, Hosam M.
Egypt, Cairo
Faculty of Medicine
Shahine, Elham A.
Egypt, Cairo
Faculty of Medicine
Ibrahim, Ahmed S.
Egypt, Cairo
Ain Shams University
Mancini-Marïe, Adham
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Collins, Donald Louis
Canada, Montreal
Mcconnell Brain Imaging Centre
Statistics
Citations: 21
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1016/j.bandc.2011.09.005
ISSN:
02782626
e-ISSN:
10902147
Research Areas
Cancer
Disability
Genetics And Genomics
Maternal And Child Health
Participants Gender
Male