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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
Cellobiose dehydrogenase functionalized urinary catheter as novel antibiofilm system
Journal of Biomedical Materials Research - Part B Applied Biomaterials, Volume 104, No. 7, Year 2016
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Description
Urinary catheters expose patients to a high risk of acquiring nosocomial infections. To prevent this risk of infection, cellobiose dehydrogenase (CDH), an antimicrobial enzyme able to use various oligosaccharides as electron donors to produce hydrogen peroxide using oxygen as an electron acceptor, was covalently grafted onto plasma-activated urinary polydimethylsiloxane (PDMS) catheter surfaces. Successful immobilization of CDH on PDMS was confirmed by Fourier transformed-infrared spectrometry and production of H2O2. The CDH functionalized PDMS surfaces reduced the amount of viable Staphylococcus aureus by 60%, total biomass deposited on the surface by 30% and 70% of biofilm formation. The immobilized CDH was relatively stable in artificial urine over 16 days, retaining 20% of its initial activity. The CDH coated PDMS surface did not affect the growth and physiology of HEK 239 and RAW 264,7 mammalian cells. Therefore this new CDH functionalized catheter system shows great potential for solving the current problems associated with urinary catheters. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1448–1456, 2016.
Authors & Co-Authors
Thallinger, Barbara
Austria, Vienna
Universitat Fur Bodenkultur Wien
Brandauer, Martin
Austria, Vienna
Universitat Fur Bodenkultur Wien
Burger, Peter
Austria, Vienna
Universitat Fur Bodenkultur Wien
Sygmund, Christoph
Austria, Vienna
Universitat Fur Bodenkultur Wien
Ludwig, Roland
Austria, Vienna
Universitat Fur Bodenkultur Wien
Ivanova, Kristina
Spain, Barcelona
Universitat Politécnica de Catalunya
Kun, Jutta
Germany, Tubingen
Synovo Gmbh
Scaini, Denis
Italy, Basovizza
Elettra-sincrotrone Trieste S.c.p.a.
Burnet, Michael
Germany, Tubingen
Synovo Gmbh
Tzanov, Tzanko
Spain, Barcelona
Universitat Politécnica de Catalunya
Nyanhongo, Gibson Stephen
Austria, Vienna
Universitat Fur Bodenkultur Wien
Botswana, Palapye
Botswana International University of Science and Technology
Guebitz, Georg M.
Austria, Vienna
Universitat Fur Bodenkultur Wien
Statistics
Citations: 12
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1002/jbm.b.33491
ISSN:
15524973
e-ISSN:
15524981