Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Unexplained diarrhoea in HIV-1 infected individuals
BMC Infectious Diseases, Volume 14, No. 1, Article 22, Year 2014
Notification
URL copied to clipboard!
Description
Background: Gastrointestinal symptoms, in particular diarrhoea, are common in non-treated HIV-1 infected individuals. Although various enteric pathogens have been implicated, the aetiology of diarrhoea remains unexplained in a large proportion of HIV-1 infected patients. Our aim is to identify the cause of diarrhoea for patients that remain negative in routine diagnostics.Methods: In this study stool samples of 196 HIV-1 infected persons, including 29 persons with diarrhoea, were examined for enteropathogens and HIV-1. A search for unknown and unexpected viruses was performed using virus discovery cDNA-AFLP combined with Roche-454 sequencing (VIDISCA-454).Results: HIV-1 RNA was detected in stool of 19 patients with diarrhoea (66%) compared to 75 patients (45%) without diarrhoea. In 19 of the 29 diarrhoea cases a known enteropathogen could be identified (66%). Next to these known causative agents, a range of recently identified viruses was identified via VIDISCA-454: cosavirus, Aichi virus, human gyrovirus, and non-A non-B hepatitis virus. Moreover, a novel virus was detected which was named immunodeficiency-associated stool virus (IASvirus). However, PCR based screening for these viruses showed that none of these novel viruses was associated with diarrhoea. Notably, among the 34% enteropathogen-negative cases, HIV-1 RNA shedding in stool was more frequently observed (80%) compared to enteropathogen-positive cases (47%), indicating that HIV-1 itself is the most likely candidate to be involved in diarrhoea.Conclusion: Unexplained diarrhoea in HIV-1 infected patients is probably not caused by recently described or previously unknown pathogens, but it is more likely that HIV-1 itself plays a role in intestinal mucosal abnormalities which leads to diarrhoea. © 2014 Oude Munnink et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Oude-Munnink, Bas B.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Canuti, Marta
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Deijs, Martin
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
de Vries, Michel
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Jebbink, Maarten F.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Rebers, Sjoerd P.H.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Molenkamp, Richard
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Cotten, Matt
United Kingdom, Hinxton
Wellcome Sanger Institute
Sol, Cees J.A.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Hoek, Lia M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Statistics
Citations: 45
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1186/1471-2334-14-22
ISSN:
14712334
Research Areas
Genetics And Genomics
Infectious Diseases