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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines
Communications Biology, Volume 3, No. 1, Article 563, Year 2020
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Description
We characterize the breadth, function and phenotype of innate and adaptive cellular responses in a prevention of Mycobacterium tuberculosis infection trial. Responses are measured by whole blood intracellular cytokine staining at baseline and 70 days after vaccination with H4:IC31 (subunit vaccine containing Ag85B and TB10.4), Bacille Calmette-Guerin (BCG, a live attenuated vaccine) or placebo (n = ~30 per group). H4:IC31 vaccination induces Ag85B and TB10.4-specific CD4 T cells, and an unexpected NKTlike subset, that expresses IFN-γ, TNF and/or IL-2. BCG revaccination increases frequencies of CD4 T cell subsets that either express Th1 cytokines or IL-22, and modestly increases IFNγ-producing NK cells. In vitro BCG re-stimulation also triggers responses by donor-unrestricted T cells, which may contribute to host responses against mycobacteria. BCG, which demonstrated efficacy against sustained Mycobacterium tuberculosis infection, modulates multiple immune cell subsets, in particular conventional Th1 and Th22 cells, which should be investigated in discovery studies of correlates of protection. © 2020, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC7547090/bin/42003_2020_1288_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC7547090/bin/42003_2020_1288_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC7547090/bin/42003_2020_1288_MOESM3_ESM.pdf
Authors & Co-Authors
Rozot, Virginie
South Africa, Cape Town
University of Cape Town
Nemes, Elisa
South Africa, Cape Town
University of Cape Town
Geldenhuys, Hennie D.
South Africa, Cape Town
University of Cape Town
Musvosvi, Munyaradzi
South Africa, Cape Town
University of Cape Town
Toefy, Asma
South Africa, Cape Town
University of Cape Town
Rantangee, Frances
South Africa, Cape Town
University of Cape Town
Makhethe, Lebohang
South Africa, Cape Town
University of Cape Town
Erasmus, Mzwandile
South Africa, Cape Town
University of Cape Town
Bilek, Nicole
South Africa, Cape Town
University of Cape Town
Mabwe, Simbarashe
South Africa, Cape Town
University of Cape Town
Finak, Greg
United States, Seattle
Fred Hutchinson Cancer Center
Fulp, William J.
United States, Seattle
Fred Hutchinson Cancer Center
Ginsberg, Ann M.
United States, Rockville
Aeras
Hokey, David A.
United States, Rockville
Aeras
Shey, Muki Shehu
South Africa, Cape Town
Aeras South Africa Endpoint Assay Laboratory
Gurunathan, Sanjay
France, Lyon
Sanofi Pasteur sa
DíazGranados, Carlos A.
France, Lyon
Sanofi Pasteur sa
Bekker, Linda-Gail Gail
South Africa, Cape Town
Desmond Tutu Health Foundation
Hatherill, Mark
South Africa, Cape Town
University of Cape Town
Scriba, Thomas Jens
South Africa, Cape Town
University of Cape Town
Abrahams, Charmaine
South Africa, Cape Town
University of Cape Town
Aderiye, Marcelene
United States, Rockville
Aeras
Africa, Hadn
South Africa, Cape Town
University of Cape Town
Albertyn, Deidre
South Africa, Cape Town
Aeras Global tb Vaccine Foundation, South Africa
Alexander, Fadia
South Africa, Cape Town
University of Cape Town
Amsterdam, Julia
South Africa, Cape Town
University of Cape Town
Andersen, Peter Lawætz
Denmark, Copenhagen
Statens Serum Institut
Arendsen, Denis
South Africa, Cape Town
University of Cape Town
Bester, Hanlie
South Africa, Cape Town
Aeras Global tb Vaccine Foundation, South Africa
Beyers, Elizabeth
South Africa, Cape Town
University of Cape Town
Botes, Natasja
South Africa, Cape Town
University of Cape Town
Botes, Janelle
South Africa, Cape Town
University of Cape Town
Braaf, Samentra
South Africa, Cape Town
University of Cape Town
Brooks, Roger
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Cloete, Yolundi
South Africa, Cape Town
University of Cape Town
Companie, Alessandro
South Africa, Cape Town
University of Cape Town
Croucher, Kristin
South Africa, Cape Town
Aeras Global tb Vaccine Foundation, South Africa
Davids, Ilse
South Africa, Cape Town
University of Cape Town
De Bruyn, Guy
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Diamond, Bongani
South Africa, Cape Town
University of Cape Town
Dlakavu, Portia
South Africa, Cape Town
University of Cape Town
Dolo, Palesa
South Africa, Cape Town
University of Cape Town
Dubel, Sahlah
United States, Rockville
Aeras
Elbring, Cindy
South Africa, Cape Town
University of Cape Town
Ellis, Ruth D.
United States, Rockville
Aeras
Erasmus, Margareth
South Africa, Cape Town
University of Cape Town
Esterhuizen, Terence
South Africa, Cape Town
University of Cape Town
Evans, Thomas George
United States, Rockville
Aeras
Fattore, Christine
United States, Rockville
Aeras
Gelderbloem, Sebastian J.
South Africa, Cape Town
Aeras Global tb Vaccine Foundation, South Africa
Gempies, Diann
South Africa, Cape Town
University of Cape Town
Goliath, Sandra
South Africa, Cape Town
University of Cape Town
Gomes, Peggy
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Gregg, Yolande
South Africa, Cape Town
University of Cape Town
Hamilton, Elizabeth M.
South Africa, Cape Town
University of Cape Town
Hanekom, Willem A.
South Africa, Cape Town
University of Cape Town
Hector, Johanna
South Africa, Cape Town
University of Cape Town
Herling, Roxane
South Africa, Cape Town
University of Cape Town
Herselman, Yulandi
South Africa, Cape Town
University of Cape Town
Hopkins, Robert
United States, Rockville
Aeras
Hughes, Jane E.
South Africa, Cape Town
University of Cape Town
Hunt, Devin
United States, Rockville
Aeras
Issel, Henry
South Africa, Cape Town
University of Cape Town
Janosczyk, Helene
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Jaxa, Lungisa
South Africa, Cape Town
University of Cape Town
Jones, Carolyn
South Africa, Cape Town
University of Cape Town
Kassiem, Jateel
South Africa, Cape Town
University of Cape Town
Keffers, Sophie
South Africa, Cape Town
University of Cape Town
Kelepu, Xoliswa
South Africa, Cape Town
University of Cape Town
Keyser, Alana T.
South Africa, Cape Town
University of Cape Town
Kieffer, Alexia
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Kromann, Ingrid
South Africa, Cape Town
Aeras South Africa Endpoint Assay Laboratory
Krüger, Sandra
South Africa, Cape Town
University of Cape Town
Lambrick, Maureen
South Africa, Cape Town
Aeras Global tb Vaccine Foundation, South Africa
Landry, Bernard S.
United States, Rockville
Aeras
Langata, Phumzile
South Africa, Cape Town
University of Cape Town
Lempicki, Maria D.
United States, Rockville
Aeras
Locas, Marie Christine
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Luabeya, Angelique Kany Kany
South Africa, Cape Town
University of Cape Town
Mactavie, Lauren
South Africa, Cape Town
University of Cape Town
Makunzi, Lydia
South Africa, Cape Town
University of Cape Town
Mangala, Pamela
South Africa, Cape Town
University of Cape Town
Maqubela, Clive
South Africa, Cape Town
University of Cape Town
Mosito, Boitumelo
South Africa, Cape Town
University of Cape Town
Mouton, Angelique Hendricks
South Africa, Cape Town
University of Cape Town
Mulenga, Humphrey
South Africa, Cape Town
University of Cape Town
Mullins, Mariana
South Africa, Cape Town
University of Cape Town
Noble, J. Alison
South Africa, Cape Town
University of Cape Town
Nombida, Onke
South Africa, Cape Town
University of Cape Town
O’Dee, Dawn
United States, Rockville
Aeras
O’Neil, Amy
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Ockhuis, Rose
South Africa, Cape Town
University of Cape Town
Omarjee, Saleha
South Africa, Cape Town
Aeras South Africa Endpoint Assay Laboratory
Opperman, Fajwa
South Africa, Cape Town
University of Cape Town
Patel, Dhaval M.
France, Lyon
Sanofi Pasteur sa
Canada, Toronto
Sanofi Pasteur
Petersen, Christel
South Africa, Cape Town
University of Cape Town
Pretorius, Abraham
South Africa, Cape Town
University of Cape Town
Pretorius, Debbie
South Africa, Cape Town
University of Cape Town
Raine, Michael
United States, Rockville
Aeras
Raphela, Rodney
South Africa, Cape Town
University of Cape Town
Rossouw, Susan
South Africa, Cape Town
University of Cape Town
Roux, Surita
South Africa, Cape Town
Desmond Tutu Health Foundation
Rutkowski, Kathryn Tucker
United States, Rockville
Aeras
Ryall, Robert
France, Lyon
Sanofi Pasteur sa
Schoeman, Elisma
South Africa, Cape Town
University of Cape Town
Schreuder, Constance
South Africa, Cape Town
University of Cape Town
Self, Steven G.
United States, Seattle
Fred Hutchinson Cancer Center
Shenje, Justin Tapiwa
South Africa, Cape Town
University of Cape Town
Shepherd, Barbara
United States, Rockville
Aeras
Siefers, Heather M.
United States, Rockville
Aeras
Sinandile, Eunice
South Africa, Cape Town
University of Cape Town
Steyn, Marcia
South Africa, Cape Town
University of Cape Town
Sutton, Sharon
United States, Rockville
Aeras
Swarts, Anne
South Africa, Cape Town
University of Cape Town
Tameris, Michele D.
South Africa, Cape Town
University of Cape Town
van der Riet, Elize
South Africa, Cape Town
University of Cape Town
van Rooyen, Elma
South Africa, Cape Town
University of Cape Town
Veldsman, Ashley
South Africa, Cape Town
University of Cape Town
Xoyana, Noncedo
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 13
Authors: 119
Affiliations: 9
Identifiers
Doi:
10.1038/s42003-020-01288-3
ISSN:
23993642