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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis
Tropical Medicine and International Health, Volume 14, No. 5, Year 2009
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Description
Objectives To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis. Methods We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic). Results were compared to standard stage determination markers and IgM intrathecal synthesis. Results CXCL-13 levels in patients' sera had a median value of 386.6 pg/ml and increased levels were associated with presence of trypanosomes in the CSF but not with other stage markers. CXCL-13 levels in patients' CSF had a median value of 80.9 pg/ml and increased levels were associated with all standard stage determination markers and IgM intrathecal synthesis. Conclusion CXCL-13 levels in CSF increased significantly during the course of HAT. Hence the value of CXCL-13 for diagnosis, follow-up or as a marker of disease severity should be tested in a well-defined cohort study. © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Courtioux, Bertrand
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Pervieux, Lynda
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Vatunga, Gedeão M.L.
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Angola, Luanda
Instituto de Combate e Controlo Das Tripanossomiases
Marin, Benoît
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
France, Limoges
Chu de Limoges
Josénando, Théophile
Angola, Luanda
Instituto de Combate e Controlo Das Tripanossomiases
Jauberteau-Marchan, M. O.
France, Limoges
Homéostasie Cellulaire et Pathologies
Bouteille, Bernard
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
France, Limoges
Chu de Limoges
Bisser, Sylvie
France, Limoges
Institut D’epidémiologie Neurologique et de Neurologie Tropicale
Statistics
Citations: 29
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-3156.2009.02263.x
ISSN:
13602276
e-ISSN:
13653156
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Angola