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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma
Infectious Agents and Cancer, Volume 6, No. 1, Article 3, Year 2011
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Description
Background: Nasopharyngeal carcinoma (NPC) is a malignant tumor which arises in surface epithelium of the posterior wall of the nasopharynx. There's is evidence that Epstein Barr virus (EBV) is associated to NPC development. However, many epidemiologic studies point to a connection between viral infections by the human papillomavirus (HPV) and NPC. Method: Seventy Moroccan patients with NPC were screened for EBV and HPV. EBV detection was performed by PCR amplification of BZLF1 gene, encoding the ZEBRA (Z Epstein-Barr Virus Replication Activator) protein, and HPV infection was screened by PCR amplification with subsequent typing by hybridization with specific oligonucleotides for HPV types 16, 18, 31, 33, 35, 45 and 59. Results: The age distribution of our patients revealed a bimodal pattern. Sixty two cases (88.9%) were classified as type 3 (undifferentiated carcinoma), 6 (8.6%) as type 2 (non keratinizing NPC) and only 2 (2.9%) cases were classified as type 1 (keratinizing NPC). EBV was detected in all NPC tumors, whereas HPV DNA was revealed in 34% of cases (24/70). Molecular analysis showed that 20.8% (5/24) were infected with HPV31, and the remaining were infected with other oncogenic types (i.e., HPV59, 16, 18, 33, 35 and 45). In addition, statistical analysis showed that there's no association between sex or age and HPV infection (P > 0.1). Conclusion: Our data indicated that EBV is commonly associated with NPC in Moroccan patients and show for the first time that NPC tumours from Moroccan patients harbour high risk HPV genotypes. © 2011 Laantri et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Laantri, Nadia
Morocco, Casablanca
Institut Pasteur du Maroc
Morocco, El Jadida
Université Chouaib Doukkali
Attaleb, M.
Morocco, Rabat
National Energy Center of Nuclear Science and Technology
Kandil, Mostafa
Morocco, El Jadida
Université Chouaib Doukkali
Naji, Fadwa
Morocco, Casablanca
Institut Pasteur du Maroc
Mouttaki, Tarik
Morocco, Casablanca
Institut Pasteur du Maroc
Dardari, R'Kia
Morocco, Casablanca
Institut Pasteur du Maroc
Belghmi, Khalid
Morocco, Casablanca
Faculté Des Sciences Aïn Chock
Benchakroun, Nadia
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
El-Mzibri, Mohammed E.
Morocco, Rabat
National Energy Center of Nuclear Science and Technology
Khyatti, Meriem
Morocco, Casablanca
Institut Pasteur du Maroc
Statistics
Citations: 42
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1186/1750-9378-6-3
e-ISSN:
17509378
Research Areas
Cancer
Genetics And Genomics
Study Approach
Quantitative