Hypoglycaemic properties of the aqueous root extract of Morinda lucida (Benth) (Rubiaceae). Studies in the mouse

The aqueous root extract of Morinda lucida (Rubiaceae) Benth, exhibited potent hypoglycaemic effects in both normoglycemic and alloxan‐induced diabetic mice by oral administration. This effect was dose‐dependent and more potent than that observed with chlorpropamide (1‐(p‐chlorobenzene‐sulphanyl)‐3‐propylurea). In the normoglycaemic mice, the extract (140 mg/kg body weight) produced a fall in blood sugar of 32% + 1% while at 280 mg/kg body weight there was a 52% + 2% fall over the same time interval. In alloxan‐induced diabetic mice, the reaction time of the extract was longer with a single dose of the extract producing a significant hypoglycaemic effect 4 h after administration. In diabetic mice, a dose of 140 mg/kg body weight of the plant extract caused a fall in blood sugar of 51% + 1% while a dose of 280 mg/kg produced a fall of 60% + 2%. Copyright © 1994 John Wiley & Sons, Ltd.