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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits
Nature Communications, Volume 12, No. 1, Article 1250, Year 2021
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Description
Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report a genome-wide association study with 45 clinically relevant traits from the population of Qatar using a whole genome sequencing approach in a discovery set of 6218 individuals and replication in 7768 subjects. Trait heritability is more similar between Qatari and European populations (r = 0.81) than with Africans (r = 0.44). We identify 281 distinct variant-trait-associations at genome wide significance that replicate known associations. Allele frequencies for replicated loci show higher correlations with European (r = 0.94) than with African (r = 0.85) or Japanese (r = 0.80) populations. We find differences in linkage disequilibrium patterns and in effect sizes of the replicated loci compared to previous reports. We also report 17 novel and Qatari-predominate signals providing insights into the biological pathways regulating these traits. We observe that European-derived polygenic scores (PGS) have reduced predictive performance in the Qatari population which could have implications for the translation of PGS between populations and their future application in precision medicine. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC7902658/bin/41467_2021_21381_MOESM1_ESM.pdf
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https://efashare.b-cdn.net/share/pmc/articles/PMC7902658/bin/41467_2021_21381_MOESM7_ESM.pdf
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Authors & Co-Authors
Thareja, Gaurav
Qatar, Doha
Weill Cornell Medicine-qatar
Al-Sarraj, Yasser A.
Qatar, Doha
Hamad Bin Khalifa University
Belkadi, Aziz
Qatar, Doha
Weill Cornell Medicine-qatar
United States, New York
Weill Cornell Medicine
Ismail, Said I.
Qatar, Doha
Qatar Foundation
Al-Muftah, Wadha Ahmed
Qatar, Doha
Qatar Foundation
Badji, Radja Messai
Qatar, Doha
Qatar Foundation
Mbarek, Hamdi
Qatar, Doha
Qatar Foundation
Saad, Chadi
Qatar, Doha
Qatar Foundation
Al-Thani, Asmaa Ali
Qatar, Doha
Qatar Foundation
Afifi, Nahla M.
Qatar, Doha
Qatar Foundation
Liu, Wei
Qatar, Doha
Sidra Medicine
Lorenz, Stephan
Qatar, Doha
Sidra Medicine
Syed, Najeeb Ashraf
Qatar, Doha
Sidra Medicine
Almabrazi, Hakeem G.
Qatar, Doha
Sidra Medicine
Temanni, Ramzi
Qatar, Doha
Sidra Medicine
al-Ali, Rashid J.
Qatar, Doha
Sidra Medicine
Albagha, Omar M.E.
Qatar, Doha
Hamad Bin Khalifa University
United Kingdom, Edinburgh
The University of Edinburgh
Chouchane, Lotfi
Qatar, Doha
Weill Cornell Medicine-qatar
Estivill, Xavier
Qatar, Doha
Sidra Medicine
Fakhro, Khalid Adnan
Qatar, Doha
Sidra Medicine
Mokrab, Younes
Qatar, Doha
Sidra Medicine
Jithesh, Puthen V.
Qatar, Doha
Hamad Bin Khalifa University
Suhre, Karsten
Qatar, Doha
Weill Cornell Medicine-qatar
United States, New York
Weill Cornell Medicine
Statistics
Citations: 32
Authors: 23
Affiliations: 8
Identifiers
Doi:
10.1038/s41467-021-21381-3
ISSN:
20411723
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study