Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High sequence diversity in infectious bursal disease virus serotype 1 in poultry and turkey suggests West-African origin of very virulent strains
Archives of Virology, Volume 149, No. 4, Year 2004
Notification
URL copied to clipboard!
Description
Fifty-eight outbreaks of Infectious bursal disease virus (IBDV) were observed in vaccinated chicken flocks in four Southwestern states of Nigeria between 1995 and 2000. Bursa samples from 40 flocks were found virus-positive in VP2-specific nested RT-PCR. Sequences of the hypervariable region of VP2 were compared to reference strains of the different IBDV variants including also 1988 isolates from Nigeria. Sequence analysis revealed that all 40 Nigerian isolates belonged to the very virulent (vv) variant. The maximum sequence diversity of 5.7% was higher than in all other vvIBDV sequences listed in Genbank (3.6%). Two clusters within Nigerian isolates are unique to this region. Serotype 1 IBDV was also detected in four symptomatic turkey flocks. The turkey isolates were found within 2 of the 3 VV-clusters of chicken isolates. Full length sequence of a turkey isolate (NIE009t) confirmed its close relation to vvIBDV strain D6948NET for both segment A (1.4% sequence diversity) and segment B (2.1%). Thus, turkeys should be considered susceptible to vvIBDV infection. The unusually high sequence diversity of vvIBDV may be an indication of a West-African origin of this virus, from where it spread to other continents. © Springer-Verlag 2004.
Authors & Co-Authors
Owoade, Ademola Amubieya
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Nigeria, Ibadan
University of Ibadan
Mulders, Mick Norman
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Kohnen, J.
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Germany, Kaiserslautern
Technische Universität Kaiserslautern
Ammerlaan, Wim
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Muller, Claude P.
Luxembourg, Luxembourg
Laboratoire National de Sante Luxembourg
Statistics
Citations: 53
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1007/s00705-003-0270-y
ISSN:
03048608
Study Locations
Nigeria