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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration
Matrix Biology, Volume 28, No. 4, Year 2009
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Description
Here, we report the purification and characterization of an acidic Asp49 phospholipase A2, named MVL-PLA2, with a molecular mass of 13,626.64 Da. The complete MVL-PLA2 cDNA was cloned from Macrovipera lebetina transmediterranea venom gland cDNA library. MVL-PLA2 possesses 122 amino acid residues, including 14 cysteines, and belongs to group II snake venom phospholipase A2 enzymes. MVL-PLA2 was not cytotoxic up to 2 μM and completely abolished cell adhesion and migration of various human tumor cells. Chemical modification with p-bromophenacyl bromide abolished the enzymatic activity of MVL-PLA2 without affecting its anti-tumor effect, suggesting the presence of 'pharmacological sites' distinct from the catalytic site in snake venom phospholipase A2. We demonstrated for the first time that the anti-tumor effect of MVL-PLA2 was mediated by α5β1 and αv-containing integrins. This finding may serve as starting point for structure-function relationship studies leading to design a new generation of specific anti-cancer drugs. © 2009 Elsevier B.V./International Society of Matrix Biology.
Authors & Co-Authors
Bazaa, Amine
Tunisia, Tunis
Institut Pasteur de Tunis
Luis, José
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Srairi-Abid, Najet
Tunisia, Tunis
Institut Pasteur de Tunis
Kallech-Ziri, Olfa
Tunisia, Tunis
Institut Pasteur de Tunis
Kessentini-Zouari, Raoudha
Tunisia, Tunis
Institut Pasteur de Tunis
Defilles, Céline
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Lissitzky, Jean Claude
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
El-Ayeb, Mohamed E.
Tunisia, Tunis
Institut Pasteur de Tunis
Marrakchi, Naziha
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Faculté de Médecine de Tunis
Statistics
Citations: 67
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.matbio.2009.03.007
ISSN:
0945053X
Research Areas
Cancer
Genetics And Genomics