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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The substantial hospitalization burden of influenza in central China: Surveillance for severe, acute respiratory infection, and influenza viruses, 2010-2012
Influenza and other Respiratory Viruses, Volume 8, No. 1, Year 2014
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Description
Background: Published data on influenza in severe acute respiratory infection (SARI) patients are limited. We conducted SARI surveillance in central China and estimated hospitalization rates of SARI attributable to influenza by viral type/subtype. Methods: Surveillance was conducted at four hospitals in Jingzhou, China from 2010 to 2012. We enrolled hospitalized patients who had temperature ≥37·3°C and at least one of: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. A nasopharyngeal swab was collected from each case-patient within 24 hours of admission for influenza testing by real-time reverse transcription PCR. Results: Of 17 172 SARI patients enrolled, 90% were aged <15 years. The median duration of hospitalization was 5 days. Of 16 208 (94%) SARI cases tested, 2057 (13%) had confirmed influenza, including 1427 (69%) aged <5 years. Multiple peaks of influenza occurred during summer, winter, and spring months. Influenza was associated with an estimated 115 and 142 SARI hospitalizations per 100 000 during 2010-2011 and 2011-2012 [including A(H3N2): 55 and 44 SARI hospitalizations per 100 000; pandemic A(H1N1): 33 SARI hospitalizations per 100 000 during 2010-2011; influenza B: 26 and 98 hospitalizations per 100 000], with the highest rate among children aged 6-11 months (3603 and 3805 hospitalizations per 100 000 during 2010-2011 and 2011-2012, respectively). Conclusions: In central China, influenza A and B caused a substantial number of hospitalizations during multiple periods each year. Our findings strongly suggest that young children should be the highest priority group for annual influenza vaccination in China. © 2013 The Authors.
Authors & Co-Authors
Yu, Hongjie
China, Beijing
Chinese Center for Disease Control and Prevention
Klena, John David
United States, Atlanta
Centers for Disease Control and Prevention
Zheng, Jiandong
China, Beijing
Chinese Center for Disease Control and Prevention
Peng, Zhibin
China, Beijing
Chinese Center for Disease Control and Prevention
Huo, Xixiang
Unknown Affiliation
Jiang, Hui
China, Beijing
Chinese Center for Disease Control and Prevention
Zhang, Yuzhi
United States, Atlanta
Centers for Disease Control and Prevention
Feng, Zijian
China, Beijing
Chinese Center for Disease Control and Prevention
Zhan, Fanxian
Unknown Affiliation
Uyeki, Timothy M.
United States, Atlanta
Centers for Disease Control and Prevention
Wang, Yu
China, Beijing
Chinese Center for Disease Control and Prevention
Varma, Jay K.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 90
Authors: 12
Affiliations: 2
Identifiers
Doi:
10.1111/irv.12205
ISSN:
17502659
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health