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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Neuropsychopharmacology, Year 2023
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Description
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions. © 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Authors & Co-Authors
Sun, Delin
United States, Durham
Brain Imaging and Analysis Center
United States, Durham
Durham va Medical Center
China, Hong Kong
The Education University of Hong Kong
Baird, C. Lexi
United States, Durham
Brain Imaging and Analysis Center
United States, Durham
Durham va Medical Center
Haswell, Courtney C.
United States, Durham
Brain Imaging and Analysis Center
United States, Durham
Durham va Medical Center
Frijling, Jessie L.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Olff, Miranda
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Zuiden, Mirjam
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Koch, Saskia B.J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Netherlands, Nijmegen
Donders Institute for Brain, Cognition and Behaviour
Nawijn, Laura
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Veltman, Dick J.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Suarez-Jimenez, Benjamin
United States, Rochester
University of Rochester Medical Center
Zhu, Xi
United States, New York
Columbia University Irving Medical Center
United States, New York
New York State Psychiatric Institute
Neria, Yuval
United States, New York
Columbia University Irving Medical Center
United States, New York
New York State Psychiatric Institute
Hudson, Anna R.
Belgium, Ghent
Universiteit Gent
Mueller, Sven C.
Belgium, Ghent
Universiteit Gent
Baker, Justin Taylor
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Lebois, Lauren A.M.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Kaufman, Milissa L.
United States, Boston
Harvard Medical School
United States, Belmont
Mclean Hospital
Dennis, Emily L.
United States, Salt Lake City
The University of Utah
United States
Va Medical Center
Ching, Christopher R.K.
United States, Los Angeles
Keck School of Medicine of Usc
Thomopoulos, Sophia I.
United States, Los Angeles
Keck School of Medicine of Usc
Salminen, Lauren E.
United States, Los Angeles
Keck School of Medicine of Usc
Jahanshad, Neda
United States, Los Angeles
Keck School of Medicine of Usc
Thompson, Paul M.
United States, Los Angeles
Keck School of Medicine of Usc
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
Koopowitz, Sheri Michelle
South Africa, Cape Town
University of Cape Town
Ipser, Jonathan C.
South Africa, Cape Town
University of Cape Town
Seedat, Soraya
South Africa, Stellenbosch
Stellenbosch University
Du Plessis, Stéfan
South Africa, Stellenbosch
Stellenbosch University
van den Heuvel, Leigh Luella
South Africa, Stellenbosch
Stellenbosch University
Wang, Li
China, Beijing
Chinese Academy of Sciences
China, Beijing
University of Chinese Academy of Sciences
Zhu, Ye
China, Beijing
Chinese Academy of Sciences
China, Beijing
University of Chinese Academy of Sciences
Sierk, Anika
Germany, Berlin
Charité – Universitätsmedizin Berlin
Manthey, Antje
Germany, Berlin
Charité – Universitätsmedizin Berlin
Walter, Henrik
Germany, Berlin
Charité – Universitätsmedizin Berlin
Daniels, Judith K.
Netherlands, Groningen
Rijksuniversiteit Groningen
Schmahl, Christian G.
Germany, Heidelberg
Universität Heidelberg
Herzog, Julia Isabell
Germany, Heidelberg
Universität Heidelberg
Liberzon, Israel
United States, College Station
Texas A&m University
King, Anthony P.J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Davenport, Nicholas D.
United States, Minneapolis
Va Midwest Health Care Network
United States, Minneapolis
University of Minnesota Twin Cities
Sponheim, Scott R.
United States, Minneapolis
Va Midwest Health Care Network
United States, Minneapolis
University of Minnesota Twin Cities
Disner, Seth G.
United States, Minneapolis
Va Midwest Health Care Network
United States, Minneapolis
University of Minnesota Twin Cities
Straube, Thomas
Germany, Munster
University of Münster
Hofmann, David Bernd
Germany, Munster
University of Münster
Grupe, Daniel W.
United States, Madison
University of Wisconsin-madison
Nitschke, Jack B.
United States, Madison
University of Wisconsin-madison
Davidson, Richard J.
United States, Madison
University of Wisconsin-madison
Larson, Christine L.
United States, Milwaukee
University of Wisconsin-milwaukee
DeRoon-Cassini, Terri A.
United States, Milwaukee
Medical College of Wisconsin
Blackford, Jennifer Urbano
United States, Omaha
University of Nebraska Medical Center
United States, Nashville
Vanderbilt University Medical Center
Gordon, Evan M.
United States, St. Louis
Washington University in St. Louis
May, Geoffrey J.
United States, Waco
Baylor University
United States, Richardson
The University of Texas at Dallas
United States, Bryan
Texas A&m University College of Medicine
Nelson, Steven M.
United States, Waco
Baylor University
United States, Richardson
The University of Texas at Dallas
United States, Bryan
Texas A&m University College of Medicine
Abdallah, Chadi G.
United States, New Haven
Yale School of Medicine
United States, Houston
Baylor College of Medicine
Levy, Ifat
United States, New Haven
Yale University
United States, West Haven
National Center for Ptsd
Harpaz-Rotem, Ilan
United States, New Haven
Yale School of Medicine
United States, New Haven
Yale University
United States, West Haven
National Center for Ptsd
Krystal, John Harrison
United States, New Haven
Yale School of Medicine
United States, West Haven
National Center for Ptsd
Morey, Rajendra A.
United States, Durham
Brain Imaging and Analysis Center
United States, Durham
Durham va Medical Center
Statistics
Authors: 58
Affiliations: 43
Identifiers
Doi:
10.1038/s41386-023-01763-5
ISSN:
0893133X
Research Areas
Maternal And Child Health
Mental Health
Substance Abuse